UCL Great Ormond Street Institute of Child Health

UCL BMSC logo2

About the Biological Mass Spectrometry Centre

The Biological Mass Spectrometry Centre (BMSC) is a state of the art research centre which is housed in bespoke laboratories at the UCL Institute of Child Health and headed by Dr Kevin Mills.  The Centre has both the capability to perform biomarker discovery type experiments and develop any of these diagnostic molecules into accredited, translational tests that can be used by the NHS and industry. The centre is a research facility but we do offer some simple service type analyses. Please contact us before applying for any grant to perform MS research as it needs to be fully costed beforehand. If you would like more information regarding what instrumentation we have then please follow the link to the technology section.  If you would like to use mass spectrometry in your research then please spend 5 minutes reading the Frequently Asked Questions before contacting us.


The centre has mass spectrometry equipment for MALDI/tissue imaging, proteomics (2D DiGE and label free mass spectrometry), metabolomics, lipidomics, glycomics and targeted proteomics (MRM based) translational test development. The BMSC is staffed by over 20 full-time researchers and has over £6 million in grant funding. Our group works very closely with the BRC at Great Ormond Street Hospital and National Hospital for Neurology in both elucidating disease mechanisms involved in genetic metabolic disease and neurodegenerative conditions.

Our Translational  Research

The BMSC is a unique, state of the art environment where both clinical and non-clinical researchers work side by side using proteomics, metabolomics and lipidomics to elucidate disease mechanisms in rare and neurodegenerative diseases. The group also specialise in biomarker discovery and translational test development for the NHS and industry, creating new, more specific and accurate tests.  These tests are of direct patient benefit and allow us to diagnose diseases much more accurately and quicker than ever before. In addition these bespoke assays are being translated into the accredited chemical pathology department at GOSH where they are used to diagnose and monitor therapy or drug trials. Further information 

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The BMSC has a history of developing specialised clinical assays which we still provide as diagnostic services. We were the first centre to develop and offer  the assay for urine Gb3 which is a marker used for diagnosis and monitoring of Fabry disease. This assay is now used around the world and we are a main centre for the assay for clinical trials.

We have also been providing a service for the analysis of urinary bile acids since 1984 that has helped diagnose many patients with inborn errors of metabolism.

BMSC logo kindly designed and provided by Adele Heywood