UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Biological Mass Spectrometry Centre

The UCL BMSC is based at the UCL Great Ormond Street Institute of Child Health and is a specialist mass spectrometry centre that supports Translational Research at UCL. The centre also provides specialist clinical assays for in-born errors of metabolism in partnership with Great Ormond Street Hospital and is supported both by the NIHR GOSH Biomedical Research Centre and self-funded through income from clinical diagnostics. Please note the centre is not a core facility. We work on a collaborative Team Science basis.

The centre houses the Translational Mass Spectrometry Research Groups of Prof Kevin Mills, Dr Wendy Heywood, Dr Philippa Mills and Prof Peter Clayton.

The BMSC has a history of developing specialised clinical assays that we have been providing for diagnostic services since 1984 with specialist analyses of urinary bile acids for inborn errors of metabolism. We were the first centre to develop the mass spectral screening method for the diagnosis and monitoring of Fabry disease. This assay is now used around the world in diagnostics and clinical trials and we are the main centre for Gb3 and lyso-Gb3 analyses in the UK through Great Ormond Street Hospital.

Since April 2020 the centre has been developing testing of Sars-CoV2 infection in healthcare workers.

The centre performs omic profiling and hypothesis generating analyses using a Waters Synapt G2 Si mass spectrometer and targeted analysis of proteins, lipids and metabolites using Waters Xevo-TQ-S triple quadrupole mass spectrometers



Biological Mass Spectrometry Centre







UCL TMSRG logo kindly designed and provided by Adele Heywood