ISPNR Agenda

Session 1: Cell and Molecular Part 1

Chairs: James Phillips and Rebecca Powell

9.15 - 9.55: Keynote lecture 1 - The multicellular complexity of peripheral nerve regeneration, Prof Alison Lloyd

9:55 - 10:10 : Preferential regeneration and collateral dynamics of motor and sensory neurons after nerve injury in mice, Sara Bolívar Martín

10:10 - 10:25    Intrinsic neuronal activation of CXCR4 in regulation of regeneration program of the primary sensory neurons, Petr Dubový

10:25 - 10:40: PDGFRα expressing fibroblasts in epineurium promote the repair of the lesion site after peripheral nerve injury by enhancing endothelial cell migration via CHRDL1 secretion, Masato Hara

10:40 - 10:55: An Innovative Technique for Stabilising and Aligning Endothelial Cells Within Nerve Repair Conduits, Poppy Smith

Session 2: Cell and Molecular Part II

Chairs: Kirsten Haastert-Talini and Poppy Smith

11:20 - 11:35: Using mouse and zebrafish models to study nerve injury and repair, Peter Arthur-Farraj

11:35 - 11:50: Towards production of tailored nerve guidance conduits by elucidating the interactions between spider silk and Schwann cells, Aida Naghilou

11:50 - 12:05: Engineered aligned nerve constructs formed using conditionally immortalised Schwann cells differentiated from human iPSCs, Rebecca Powell

12:05 - 12:20    The role of class IIa HDACs in aged Schwann cells and regeneration of the aged peripheral nerve, Jose Antonio Gomez-Sanchez

12:20 - 12:35    Electromagnetic challenges to Schwann cell: friend or foe for peripheral nerve regeneration? Valerio Magnaghi

12:35 - 12:50    Minocycline in nerve regeneration: insights from in vitro experiments, Owein Guillemot-Legris

Session 3: Emerging technologies and multidisciplinary approaches

Chairs: Rebecca Shipley and Simao Laranjeira

2:30- 3:10:  Keynote lecture 2: Extracorporeal shockwave therapy of peripheral nerves and 3D imaging of nervous tissue, Dr David Hercher

3:10 - 3:25: Gut-PNS axis: a new interaction between gut microbiota and peripheral nervous system, Giulia Ronchi

3:25 - 3:40: Sutureless Nerve Coaptation Leveraging a Bioinspired Light-Activated Polymer Platform: Poly Glycerol Sebacate Acrylate (PGSA), Dominic Power

3:40 - 3:55: Mathematical modelling of regenerative angiogenesis to define strategies for peripheral nerve repair, Maxime Berg

3:55 - 4:10: Automated Calculation of Functional Recovery Metrics for Nerve Injury Repair using Convolution Neuronal Networks, Simão Laranjeira

4:10 - 4:25    Changes in sciatic nerve histomorphometric parameters of the porcine sciatic nerve depending on preservation conditions after traumatic limb amputation    Kirsten Haastert-Talini

Session 4: Biomaterials and Tissue Engineering - Part I

Chairs: Victor Carriel and Maxime Berg

9:10 – 9:50: Keynote Lecture 3 - Nano-engineered platforms for peripheral nerve regeneration, Prof Orit Shefi
9:50 - 10:05: Next-generation bioactivated devices for peripheral nerve injury recovery: a comparative pre-clinical study, Elena Stocco

10:05 - 10:20: Development of chitosan microstructured and functionalized membranes for improving regenerative capabilities of peripheral nervous cells, Federica Fregnan

10:20 - 10:35: Strategies to improve the regeneration of prostatic nerves after radical prostatectomy, Luisa Muratori

Session 5: Biomaterials and Tissue Engineering - Part II

Chairs: Lars Dahlin and Holly Gregory

Neural Tissue Engineering using Conductive Biomaterials, Ryan Trueman

Modified Amino-silane coated Polycaprolactone for Peripheral Nerve Repair, Caroline S. Taylor

In vivo preclinical evaluation of acellular nerve allografts generated by a new chemo-enzimatic decellularization method, Óscar Garcia

Graphene and WS2 as neuronal interfaces: effect on cell viability, neurite outgrowth and electrophysiological properties, Domenica Convertino

Graphene-based electrode for interfacing the peripheral nerve in neuroprostheses, Xavier Navarro

Session 6: Regenerative Therapies

Chairs: Stefania Raimondo and Ryan Trueman

Keynote Lecture 4: Electrical stimulation of peripheral nerves promotes regeneration after peripheral and central nerve injuries, Prof Tessa Gordon

Heat shock proteins in the posterior interosseus nerve among subjects with type 1 and type 2 diabetes compared to healthy controls – indicators for neuroprotection? Lars Dahlin

Sandwich-structured electrospun biomaterials with encapsulated therapeutics and aligned architecture for treatment of peripheral nerve injury, Holly Gregory

Correlation between PPARγ affinity and ability of candidate drugs to promote nerve regeneration, Melissa Rayner

Blood vessels: the red carpet walked by “repair” Schwann cells to colonize nerve conduits, Giovanna Gambarotta

Session 7: Clinical translation

Chairs: Tom Quick and Melissa Rayner

Keynote Lecture 5: Translational Research in Peripheral Nerve Surgery: A Personal Journey, Mr Dominic Power

Volumetric MRI is a promising outcome measure of muscle reinnervation, Matthew Wilcox

The lived experience of motor recovery of elbow flexion via nerve transfer: A phenomenological analysis, Hazel Brown

An assessment of fatigue and co-contraction following nerve transfer to reanimate elbow flexors, Tom Quick

Animal Models for Peripheral Nerve Regeneration - It's Time to Grow Up, Rui Alvites