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2021

List of Whitehall II publications by Whitehall II researchers, ordered alphabetically by first author. This list includes consortia papers. 

  • Genome-wide association study of circulating interleukin 6 levels identifies novel loci.  Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben-Shlomo Y, Bis JC, Mitchell BD, de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater-Lleal M, Naderi E, Seppälä I, Shah T, Singhal G, Standl M, Teumer A, Thalamuthu A, Thiering E, Trompet S, Ballantyne CM, Benjamin EJ, Casas JP, Toben C, Dedoussis G, Deelen J, Durda P, Engmann J, Feitosa MF, Grallert H, Hammarstedt A, Harris SE, Homuth G, Hottenga JJ, Jalkanen S, Jamshidi Y, Jawahar MC, Jess T, Kivimaki M, Kleber ME, Lahti J, Liu Y, Marques-Vidal P, Mellström D, Mooijaart SP, Müller-Nurasyid M, Penninx B, Revez JA, Rossing P, Räikkönen K, Sattar N, Scharnagl H, Sennblad B, Silveira A, Pourcain BS, Timpson NJ, Trollor J; CHARGE Inflammation Working Group, van Dongen J, Van Heemst D, Visvikis-Siest S, Vollenweider P, Völker U, Waldenberger M, Willemsen G, Zabaneh D, Morris RW, Arnett DK, Baune BT, Boomsma DI, Chang YC, Deary IJ, Deloukas P, Eriksson JG, Evans DM, Ferreira MA, Gaunt T, Gudnason V, Hamsten A, Heinrich J, Hingorani A, Humphries SE, Jukema JW, Koenig W, Kumari M, Kutalik Z, Lawlor DA, Lehtimäki T, März W, Mather KA, Naitza S, Nauck M, Ohlsson C, Price JF, Raitakari O, Rice K, Sachdev PS, Slagboom E, Sørensen TIA, Spector T, Stacey D, Stathopoulou MG, Tanaka T, Wannamethee SG, Whincup P, Rotter JI, Dehghan A, Boerwinkle E, Psaty BM, Snieder H, Alizadeh BZ. Hum Mol Genet. 30(5):393-409, 2021 (PMID: 33517400)
  • Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging. Anatürk M, Kaufmann T, Cole JH, Suri S, Griffanti L, Zsoldos E, Filippini N, Singh-Manoux A, Kivimäki M, Westlye LT, Ebmeier KP, de Lange AG.  Hum Brain Mapp. 42(6):1626-1640, 2021 (PMID: 33314530) 
  • Serum transthyretin and risk of cognitive decline and dementia: 22-year longitudinal study. Araghi M, Shipley MJ, Anand A, Mills NL, Kivimaki M, Singh-Manoux A, Tabák A, Sabia S, Brunner EJ. Neurol Sci. 42(12):5093-5100, 2021 (PMID: 33770310)
  • Association Between Age at Diabetes Onset and Subsequent Risk of Dementia. Barbiellini Amidei C, Fayosse A, Dumurgier J, Machado-Fragua MD, Tabak AG, van Sloten T, Kivimäki M, Dugravot A, Sabia S, Singh-Manoux A. JAMA. 325(16):1640-1649, 2021 (PMID: 33904867)
  • Maternal separation in childhood and hair cortisol concentrations in late adulthood. Bevan K, Kumari M. Psychoneuroendocrinology. 130:105253, 2021 (PMID: 34051654)
  • Sex differences and the role of education in cognitive ageing: analysis of two UK-based prospective cohort studies. Bloomberg M, Dugravot A, Dumurgier J, Kivimaki M, Fayosse A, Steptoe A, Britton A, Singh-Manoux A, Sabia S. Lancet Public Health. 6(2):e106-e115, 2021 (PMID: 33516287)
  • Integrating large-scale neuroimaging research datasets: Harmonisation of white matter hyperintensity measurements across Whitehall and UK Biobank datasets.  Bordin V, Bertani I, Mattioli I, Sundaresan V, McCarthy P, Suri S, Zsoldos E, Filippini N, Mahmood A, Melazzini L, Laganà MM, Zamboni G, Singh-Manoux A, Kivimäki M, Ebmeier KP, Baselli G, Jenkinson M, Mackay CE, Duff EP, Griffanti L. Neuroimage. 15;237:118189, (PMID: 34022383) 
  • Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.  Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M, Tabak A, Singh-Manoux A, Wilson J, Langenberg C, Wareham N, Boniface D, Hingorani A, Kivimäki M, Llewellyn C.  Int J Obes (Lond). 45(4):758-765, 2021 (PMID: 33446837)
  • Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies.  Carmeli C, Kutalik Z, Mishra PP, Porcu E, Delpierre C, Delaneau O, Kelly-Irving M, Bochud M, Dhayat NA, Ponte B, Pruijm M, Ehret G, Kähönen M, Lehtimäki T, Raitakari OT, Vineis P, Kivimäki M, Chadeau-Hyam M, Dermitzakis E, Vuilleumier N, Stringhini S. Sci Rep 11(1):3100, 2021 (PMID: 33542415)
  • Genome-Wide Association Study Identifies Two Novel Loci Associated with Female Stress and Urgency Urinary Incontinence. Cartwright R, Franklin L, Tikkinen KAO, Kalliala I, Miotla P, Rechberger T, Offiah I, McMahon S, O'Reilly B, Lince S, Kluivers K, Post WM, Poelmans G, Palmer MR, Wessells H, Wong A, Kuh D, Kivimaki M, Kumari M, Mangino M, Spector T, Guggenheim JA, Lehne B, De Silva NMG, Evans DM, Lawlor D, Karhunen V, Männikkö M, Marczak M, Bennett PR, Khullar V, Järvelin MR, Walley A. J Urol. 206(3):679-687, 2021 (PMID: 33904754)
  • Joint association between accelerometry-measured daily combination of time spent in physical activity, sedentary behaviour and sleep and all-cause mortality: a pooled analysis of six prospective cohorts using compositional analysis. Chastin S, McGregor D, Palarea-Albaladejo J, Diaz KM, Hagströmer M, Hallal PC, van Hees VT, Hooker S, Howard VJ, Lee IM, von Rosen P, Sabia S, Shiroma EJ, Yerramalla MS, Dall P. Br J Sports Med. 55(22):1277-1285, 2021 (PMID: 34006506)
  • The trans-ancestral genomic architecture of glycemic traits. Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, Boutin TS, et al.  Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC). . Nat Genet. 53(6):840-860, 2021 (PMID: 34059833) 
  • Workplace discrimination as risk factor for long-term sickness absence: Longitudinal analyses of onset and changes in workplace adversity. Clark A, Stenholm S, Pentti J, Salo P, Lange T, Török E, Xu T, Fabricius J, Oksanen T, Kivimäki M, Vahtera J, Hulvej Rod N. PLoS One. 16(8):e0255697, 2021 (PMID: 34351965) 
  • Adverse Childhood Experiences and the Risk of Coronary Heart Disease in Adulthood: Examining  Potential Psychological, Biological, and Behavioral Mediators in the Whitehall II Cohort Study. Deschênes SS, Kivimaki M, Schmitz N. J Am Heart Assoc.10(10):e019013. 2021(PMID: 33938232)
  • Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies.  Frank P, Jokela M, Batty GD, Cadar D, Steptoe A, Kivimäki M. Am J Psychiatry. 178(12):1107-1118, 2021 (PMID: 34645276)
  • The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study. Gharbi-Meliani A, Dugravot A, Sabia S, Regy M, Fayosse A, Schnitzler A, Kivimäki M, Singh-Manoux A, Dumurgier J. Alzheimers Res Ther. 4;13(1):5, 2021 (PMID: 33397450) 
  • Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Gordillo-Marañón M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, Engmann J, Chaturvedi N, Papacosta O, Wannamethee G, Wong A, Sofat R, Kivimaki M, Price JF, Hughes AD, Gaunt TR, Lawlor DA, Gaulton A, Hingorani AD, Schmidt AF, Finan C. Nat Commun. 12(1):6120, 2021 (PMID: 34675202) 
  • Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. GBD 2019 Tobacco Collaborators. Lancet. 397(10292):2336, 2021 (PMID: 34051883) .
  • Does life satisfaction reduce risk of incident hypertension and stroke? Evidence from the Whitehall II cohort. Guimond AJ, Kubzansky LD, Boehm JK, Kivimaki M, Trudel-Fitzgerald C. J Psychosom Res. 144:110414, 2021 (PMID: 33711634)
  • Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study.  Hansen CS, Jørgensen ME, Malik M, Witte DR, Brunner EJ, Tabák AG, Kivimäki M, Vistisen D. Diabetes Care. 44(4):1012-1019, 2021 (PMID: 33526428) 
  • Diurnal pattern of salivary cortisol and progression of aortic stiffness: Longitudinal study. Ikeda A, Steptoe A, Shipley M, Abell J, Kumari M, Tanigawa T, Iso H, Wilkinson IB, McEniery CM, Singh-Manoux A, Kivimaki M, Brunner EJ. Psychoneuroendocrinology. 133:105372, 2021 (PMID: 34517196) 
  • Lower values of a novel index of Vagal-Neuroimmunomodulation are associated to higher all-cause mortality in two large general population samples with 18 year follow up. Jarczok MN, Koenig J, Thayer JF. Sci Rep. 11(1):2554, 2021 (PMID: 33510335) 
  • Establishing reference intervals for triglyceride-containing lipoprotein subfraction metabolites measured using nuclear magnetic resonance spectroscopy in a UK population. Joshi R, Wannamethee G, Engmann J, Gaunt T, Lawlor DA, Price J, Papacosta O, Shah T, Tillin T, Whincup P, Chaturvedi N, Kivimaki M, Kuh D, Kumari M, Hughes AD, Casas JP, Humphries SE, Hingorani AD, Schmidt AF; UCLEB Consortium. Ann Clin Biochem. 58(1):47-53, 2021 (PMID: 32936666)
  • Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies. Kivimäki M, Walker KA, Pentti J, Nyberg ST, Mars N, Vahtera J, Suominen SB, Lallukka T, Rahkonen O, Pietiläinen O, Koskinen A, Väänänen A, Kalsi JK, Goldberg M, Zins M, Alfredsson L, Westerholm PJM, Knutsson A, Theorell T, Ervasti J, Oksanen T, Sipilä PN, Tabak AG, Ferrie JE, Williams SA, Livingston G, Gottesman RF, Singh-Manoux A, Zetterberg H, Lindbohm JV. BMJ. 374:n1804, 2021 (PMID: 34407988)
  • Timeline of pain before dementia diagnosis: a 27-year follow-up study.  Kumaradev S, Fayosse A, Dugravot A, Dumurgier J, Roux C, Kivimäki M, Singh-Manoux A, Sabia S. Pain. 162(5):1578-1585, 2021 (PMID: 33003109) 
  • Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.  Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, ... Prokopenko I; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC).  Nat Commun. 12(1):24, 2021 (PMID: 33402679) 
  • Terminal decline in objective and self-reported measures of motor function before death: 10 year follow-up of Whitehall II cohort study. Landré B, Fayosse A, Ben Hassen C, Machado-Fragua MD, Dumurgier J, Kivimaki M, Sabia S, Singh-Manoux A. BMJ. 374:n1743, 2021 (PMID: 34348957)
  • Association between change in cardiovascular risk scores and future cardiovascular disease: analyses of data from the Whitehall II longitudinal, prospective cohort study.  Lindbohm JV, Sipilä PN, Mars N, Knüppel A, Pentti J, Nyberg ST, Frank P, Ahmadi-Abhari S, Brunner EJ, Shipley MJ, Singh-Manoux A, Tabak AG, Batty GD, Kivimäki M. Lancet Digit Health. 3(7):e434-e444, 2021 (PMID: 34167764)
  • Psychiatric disorders as risk factors for type 2 diabetes: An umbrella review of systematic reviews with and without meta-analyses. Lindekilde N, Rutters F, Erik Henriksen J, Lasgaard M, Schram MT, Rubin KH, Kivimäki M, Nefs G, Pouwer F. Diabetes Res Clin Pract. 176:108855, 2021 (PMID: 33965448)
  • Comparison of the predictive accuracy of multiple definitions of cognitive impairment for incident dementia: a 20-year follow-up of the Whitehall II cohort study. Machado-Fragua MD, Dugravot A, Dumurgier J, Kivimaki M, Sommerlad A, Landré B, Fayosse A, Sabia S, Singh-Manoux A. Lancet Healthy Longev, 2(7):e407-e416, 2021 (PMID: 34240063) 
  • Prospective increases in depression symptoms and markers of inflammation increase coronary heart disease risk - The Whitehall II cohort study. Piantella S, Dragano N, Marques M, McDonald SJ, Wright BJ. J Psychosom Res. 151:110657, 2021 (PMID: 34743953)
  • Associations of Total Legume, Pulse, and Soy Consumption with Incident Type 2 Diabetes: Federated Meta-Analysis of 27 Studies from Diverse World Regions.  Pearce M, Fanidi A, Bishop TRP, Sharp SJ, Imamura F, Dietrich S, Akbaraly T, Bes-Rastrollo M, Beulens JWJ, Byberg L, Canhada S, Molina MDCB, Chen Z, Cortes-Valencia A, Du H, Duncan BB, Härkänen T, Hashemian M, Kim J, Kim MK, Kim Y, Knekt P, Kromhout D, Lassale C, Ridaura RL, Magliano DJ, Malekzadeh R, Marques-Vidal P, Martínez-González MÁ, O'Donoghue G, O'Gorman D, Shaw JE, Soedamah-Muthu SS, Stern D, Wolk A, Woo HW; EPIC-InterAct Consortium, Wareham NJ, Forouhi NG. J Nutr. 151(5):1231-1240, 2021 (PMID: 33693815) 
  • Metabolic profiles of socio-economic position: a multi-cohort analysis.  Robinson O, Carter AR, Ala-Korpela M, Casas JP, Chaturvedi N, Engmann J, Howe LD, Hughes AD, Järvelin MR, Kähönen M, Karhunen V, Kuh D, Shah T, Ben-Shlomo Y, Sofat R, Lau CE, Lehtimäki T, Menon U, Raitakari O, Ryan A, Providencia R, Smith S, Taylor J, Tillin T, Viikari J, Wong A, Hingorani AD, Kivimäki M, Vineis P. Int J Epidemiol. 50(3):768-782, 2021 (PMID: 33221853) 
  • Contribution of 20-year body mass index and waist circumference history to poor cardiometabolic health in overweight/obese and normal weight adults: A cohort study. Robson E, Norris T, Costa S, Kivimäki M, Hamer M, Johnson W. Nutr Metab Cardiovasc Dis. 31(10):2851-2859, 2021 (PMID: 34340899)
  • Life-course socioeconomic disadvantage and lung function: a multicohort study of 70 496 individuals. Rocha V, Fraga S, Moreira C, Carmeli C, Lenoir A, Steptoe A, Giles G, Goldberg M, Zins M, Kivimäki M, Vineis P, Vollenweider P, Barros H, Stringhini S; LIFEPATH Consortium; members of the LIFEPATH Consortium. Eur Respir J. 57(3):2001600, 2021 (PMID: 33214206)
  • A Pathophysiology of Type 2 Diabetes Unrelated to Metabolic Syndrome.  Rottenkolber M, Gar C, Then C, Wanger L, Sacco V, Banning F, Potzel AL, Kern-Matschilles S, Nevinny-Stickel-Hinzpeter C, Grallert H, Hesse N, Seissler J, Lechner A. J Clin Endocrinol Metab. 106(5):1460-1471, 2021 (PMID: 33515032) 
  • Association of sleep duration in middle and old age with incidence of dementia. Sabia S, Fayosse A, Dumurgier J, van Hees VT, Paquet C, Sommerlad A, Kivimäki M, Dugravot A, Singh-Manoux A. Nat Commun.12(1):2289, 2021 (PMID: 33879784)
  • Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease. Schmidt AF, Hunt NB, Gordillo-Marañón M, Charoen P, Drenos F, Kivimaki M, Lawlor DA, Giambartolomei C, Papacosta O, Chaturvedi N, Bis JC, O'Donnell CJ, Wannamethee G, Wong A, Price JF, Hughes AD, Gaunt TR, Franceschini N, Mook-Kanamori DO, Zwierzyna M, Sofat R, Hingorani AD, Finan C. Nat Commun. 2021 Sep 24;12(1):5640, 2021 (PMID: 34561430)
  • SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. SCORE2 working group and ESC Cardiovascular risk collaboration.  Eur Heart J. 42(25):2439-2454. (PMID: 34120177)
  • The Role of Facets of Job Satisfaction in the National and Socioeconomic Differences in Overall Job Satisfaction: A Comparison Between Studies of Civil Servants in Great Britain and Japan. Tatsuse T, Sekine M, Yamada M, Cable N, Chandola T, Marmot MG.  J Occup Environ Med. 63(8):679-685, PMID: 34397660) 
  • Subjective Cognitive Complaints Given in Questionnaire: Relationship With Brain Structure, Cognitive Performance and Self-Reported Depressive Symptoms in a 25-Year Retrospective Cohort Study.   Topiwala A, Suri S, Allan C, Zsoldos E, Filippini N, Sexton CE, Mahmood A, Singh-Manoux A, Mackay CE, Kivimäki M, Ebmeier KP. Am J Geriatr Psychiatry. 29(3):217-226, 2021 (PMID: 32736919)
  • Association of circulating metabolites in plasma or serum and risk of stroke: Meta-analysis from seven prospective cohorts.  Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM. Neurology. 96(8):e1110-e1123, 2021 (PMID: 33268560) 
  • Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Wagner R, Heni M, Tabák AG, Machann J, Schick F, Randrianarisoa E, Hrabě de Angelis M, Birkenfeld AL, Stefan N, Peter A, Häring HU, Fritsche A.  Nat Med. 27(1):49-57, 2021 (PMID: 33398163)
  • Association of daily composition of physical activity and sedentary behaviour with incidence of cardiovascular disease in older adults. Yerramalla MS, McGregor DE, van Hees VT, Fayosse A, Dugravot A, Tabak AG, Chen M, Chastin SFM, Sabia S. Int J Behav Nutr Phys Act. 18(1):83, 2021 (PMID: 34247647)