New Paper from Jonathan Ashmore is Journal of Physiology Editors Choice
16 December 2019
Paper's title is "Wnts control membrane potential in mammalian cancer cells"
A new paper from Prof Jonathan Ashmore and colleagues is a Journal of Physiology Editors Choice from the 15th December 2019 issue. The Editors choice recognises significant papers throughout the year.
It is also the second time a UCL Ear Institute Image has made it to the front cover. The colourful microscopy image above depicts a Wnt Ligand (indicated by a red Alexa647 dye) being delivered to a prostate cancer PC3 cell loaded with the calcium indicator 0GB5N (green) through a patch pipette.
The paper is a collaboration between the Ear Institute, the Centre for Stem Cells and Regenerative Medicine at KCL and Sophion, a Danish company making a high-throughput patch clamp systems.
Commenting on the paper Prof Ashmore said "This is definitely an interdisciplinary paper - where electrophysiology meets the cancer biology field - but shows that Wnt peptides, important developmental signals for the cochlea too, unexpectedly modulate the electrical activity in some cells"