2024

• Keuss et al. 2024. Rates of cortical thinning in Alzheimer's disease signature regions associate with vascular burden but not with β -amyloid status in cognitively normal adults at age 70. J Neurol eurosurg Psychiatry. Jan 10:jnnp-2023-332067.
• Green et al. 2024. Common infections and neuroimaging markers of dementia in three UK cohort studies. Alzheimers Dement. Jan 22. Online ahead of print. 
• Murray-Smith et al. 2024. Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3. BMC Neurol. Jan 23;24(1):40.

2023

• James et al. 2023. Adulthood cognitive trajectories over 26 years and brain health at age 70: Findings from the 1946 British Birth Cohort. Neurobiol Aging. Feb122:22-32.
• Green et al. 2023. Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease. Alzheimer’s Res Ther. Feb 22;15(1):38.
• James et al. 2023. Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort. J Neurol Neurosurg Psychiatry. May;94(5):349-356.
• Coath et al. 2023. Operationalizing the centiloid scale for [18F]florbetapir PET studies on PET/MRI. Alzheimers Dement (Amst). May 16;15(2):e12434.
• Needham et al. 2023. A comprehensive assessment of age at menopause with well-characterized cognition at 70 years: A population-based British birth cohort. Maturitas. Apr; 1701:31-38.
• James et al. 2023. Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds: A population-based study. Brain Commun. Aug 18;5(5):fcad225.
• Bollack et al. 2023. Evaluation of novel data-driven metrics of amyloid β depoisition for longitudinal PET studies. Neuroimage. Oct 15:280:120313

2022

• Keuss et al. 2022. Associations of amyloid-β and vascular burden with rates of neurodegeneration in cognitively normal members of the 1946 British birth cohort. Neurology. July 12;99(2):e129-e141.
• Fatih et al. 2022. Sex-related differences in whole brain volumes at age 70 in association with hyperglycemia during adult life. Neurobiol Aging. Apr;112:161-169.
• Sliz et al. 2022. CIrculating metabolome and white matter hyperintensities in women and men. Circulation. Apr 5;145(14):1040-1052.
• Dercon et al. 2022. Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort. BMC Geriatr. Aug 21;21(1):475.
• Mason et al. 2022. Association between carotid atherosclerosis and brain activation patterns during the Stroop task in older adults: an fNIRS investigation. Neuroimage. Aug 15;257:119302.
• Wagen et al. 2022. Life course, genetic and neuropathological associations with brain age: a study of the British 1946 Birth Cohort. Lancet Healthy Longev. Sep;3(9):e6-7-e616.
• Richards et al. 2022. Straight and Divergent Pathways to Cognitive State: Seven Decades of Follow-Up in the British 1946 Birth Cohort. J Alzheimers Dis. 89(2):659-667

2021

• Keshavan et al. 2021. Population-based blood screening for pre-clinical Alzheimer’s disease in a British birth cohort at age 70. Brain. Mar 3;144(2):434-449.
• Lu et al. 2021. Visuomotor integration deficits are common to familial and sporadic preclinical Alzheimer’s disease. Brain Commun. Jan 25;3(1):fcab003.
• James et al. 2021. A population-based study of head injury, cognitive function and pathological markers. Ann Clin Transl Neurol. Apr;8(4):842-856.
• Keshavan et al. 2021. Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays. Alzheimers Dement (Amst). Feb 6;13(1):e12131. Diagnosis, Assessment & Disease Monitoring. 13:e12131.
• Lane et al. 2021. Investigating the relationship between BMI across adulthood and late life brain pathologies. Alzheimers Res Ther. Apr 30;13(1):91.
• Belloy et al. 2021. KL*VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE*4 carriers. Neurobiol Aging. May:101:123-129.
• Pavisic et al. 2021 Subjective cognitive complaints at age 70: Associations with amyloid and mental health. J Neurol Neurosurg Psychiatry. Nov;92(11):1215-1221.
• Dercon et al. 2021. Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort. BMC Geriat. Sep 29;21(1):518.
• Lu et al. 2021. Dissociable effects of APOE-ε4 and β-amyloid pathology on visual working memory. Nat Aging. Nov;1(11):1002-1009.

2020

• Lu et al. 2020. Increased variability in reaction time is associated with amyloid beta pathology at age 70. Alzheimers Dement. 12(1):e12076
• Buchanan et al. 2020. Olfactory testing does not predict β‑amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort. J Neurol.267(11):3329-3336.
• Tektonidis et al. 2020. Diet quality in late midlife is associated with faster walking speed in later life in women, but not men: findings from a prospective British birth cohort. Br J Nutr. Apr 28;123(8):913-921.
• Mason et al. 2020. et al. Study Protocol - Insight 46 Cardiovascular: A sub-study of the MRC National Survey of Health and Development. Artery Res. 26(3):170-179.

2019

• Parker et al. 2019. Pure tone audiometry and cerebral pathology in healthy older adults. J Neurol Neurosurg Psychiatry. 91(2):172-176. 
• Keuss et al. 2019. Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort. BMJ Open. 9(7):e029502.
• Parker et al. 2019. Hippocampal subfield volumes and pre-clinical Alzheimer’s disease in 408 cognitively normal adults born in 1946. PLoS One. 14(10):e0224030.
• Lane et al. 2019. Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study. Lancet Neurol. 18(10):942-952.
• Lane et al. 2019. Associations between vascular risk across adulthood and brain pathology in late life - evidence from a British birth cohort. JAMA Neurol. 77(2):1-9.
• Lu et al. 2019. Cognition at age 70: Life course predictors and associations with brain pathologies. Neurology. 93(23):e2144-e2156.
• Parker et al. 2020. Amyloid B influences the relationship between cortical thickness and vascular load. Alzheimers Dement. 12(1):e12022. 

2018

• James et al. 2018. Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46. BMC Res Notes. 11(1):885.

2017

• Lane CA, Parker TD, et al. 2017. Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development. BMC Neurol. 17(1):75.