Cell Delivery

We are investigating the use of bespoke TIPS microspheres (CytoStrat) designed specifically as a novel tool for bioprocessing and cell delivery.

Cells attach readily to the surface of TIPS microspheres, where they can be expanded and/or differentiated before being delivered in a minimally invasive manner to the target site.

A unique feature of TIPS microspheres is their combined ability to expand cells in vitro and deliver cells in vivo whilst still attached to the biodegradable microspheres without the need for further processing or cell detachment. Since the particles are qualified for clinical use this opens up a range of potential clinical applications.

Once implanted, the packed microspheres provide an open porous structure that allows nutrients diffusion to the delivered cells before it eventually degrades.

We have received funding from the UK Medical Research Council for a project investigating the use of TIPS microspheres for delivery of myoblasts (muscle pre-cursor cells) to sites of tissue injury resulting in volumetric muscle loss. We are using pre-clinical models to simulate sphincter muscle injury commonly sustained during childbirth, which is a leading cause of incontinence. The project will help determine the feasibility of using cells attached to TIPS microspheres for regeneration of damaged muscle and will help guide planned early phase clinical studies.

We are collaborating on a range of projects investigating the use of TIPS microspheres for cell delivery for clinical conditions, as well as tools for cell expansion. Please contact us if you are interested in collaborating or sourcing TIPS microspheres.