Day Lab



Selected publications 2024

  • Ho HMK, Day RM, Craig DQM. An investigation into the effects of processing factors on the properties and scaling-up potential of propranolol-loaded chitosan nanogels. Pharmaceutics. 2024
  • Bettini A, Patrick PS, Day RM, Stuckey DJ. ­­CT-Visible Microspheres Enable Whole-body In Vivo Tracking of Injectable Tissue Engineering ScaffoldsAdvanced Healthcare Materials. 2024 Apr 28:e2303588. doi: 10.1002/adhm.202303588
  • Erdogan ZK, Nandin M, GS Jin, Yu-Meng L, Chau D, Day R, Kim H, Knowles, JC. Lithium-loaded GelMA-PGFs constructs: implications for astrocyte response and regeneration. Journal of Biomedical Materials Research Part A. 2024 Jul;112(7):1070-1082. doi: 10.1002/jbm.a.37686

Selected publications 2023

  • Gilbert M, Čaputová S, Poli D, Kooy M, Sturt G, Parker J, Day RM. Building rings with spheres: a cell therapy approach to incontinence. BioInsights. 2023 DOI: 10.18609/cgti.2023.167
  • McCord B, Day RM. Cytotoxic Immune Cells Do Not Affect TDP-43 and p62 Sarcoplasmic Aggregation But Influence TDP-43 Localisation. Scientific Reports. 2023 DOI: 10.1038/s41598-023-42824-5  https://rdcu.be/dmP0T
  • Cartaxo AL, Fernandes-Platzgummer A, Rodrigues CAV, Melo AM, Tecklenburg K, Margreiter E, Day RM, da Silva CL, Cabral JMS. Developing a Cell-Microcarrier Tissue Engineered Product for Muscle Repair Using a Bioreactor System. Tissue Engineering, Part C. 2023 doi: 10.1089/ten.TEC.2023.0122
  • McCord B, Day RM. Influence of Inflammatory Cytokines IL-1β and IFNγ on Sarcoplasmic Aggregation of p62 and TDP-43 in Myotubes. Mediators of Inflammation 2023 doi: 10.1155/2023/9018470
  • Casajuana ME, Day RM. Production and Utility of Extracellular Vesicles with 3D Culture Methods. Pharmaceutics 2023. https://doi.org/10.3390/ pharmaceutics15020663

Selected publications 2022

  • Desprez C, Danovi D, Knowles CH, Day RM. Cell Shape Characteristics of Human Skeletal Muscle Cells as a Predictor of Myogenic Competency: A New Paradigm Towards Precision Cell Therapy. Journal of Tissue Engineering. Nov 2022. DOI: 10.1177/20417314221139794
  • Ho HMK, Sembi S, Abukhamees S, Day RM, Craig DQM. An analytical quality by design approach towards a simple and novel HPLC-UV method for quantification of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline. Analytical Biochemistry. June 2022. https://doi.org/10.1016/j.ab.2022.114793
  • Ho HMK, Craig DQM, Day RM. Design of Experiment Approach to Modeling the Effects of Formulation and Drug Loading on the Structure and Properties of Therapeutic Nanogels. Mol Pharm. 2022 Jan 21. doi: 10.1021/acs.molpharmaceut.1c00699. 

Selected publications 2021

  • Hanczar M, Moazen M, Day R. The Significance of Biomechanics and Scaffold Structure for Bladder Tissue Engineering. Int. J. Mol. Sci. 2021, 22, 12657. DOI:10.3390/ijms222312657
  • Hendow EK, Day RM. A facile approach to therapeutic angiogenesis using a platelet concentrate and microsphere composite. Nanoselect. Nov 2021. DOI: 10.1002/(ISSN)2688-4011
  • Keskin-Erdogan Z,  Patel KD, Chau DYS, Day RM, Kim H-W, Knowles J. Utilization of GelMA with Phosphate Glass Fibers for Glial Cell Alignment. Journal of Biomedical Materials Research: Part A 2021; 109: 2212-2224. https://doi.org/10.1002/jbm.a.37206
  • Ho HMK, Craig DQM, Day RM. Access Routes, Devices and Guidance Methods for Intrapericardial Delivery in Cardiac Conditions. Trends in Cardiovascular Medicine April 2021. https://doi.org/10.1016/j.tcm.2021.04.004

Selected publications 2020

  • Paliashvili K, Popov A, Kalber TL, Patrick PS, Hayes A, Henley A, Raynaud FI, Ahmed HU, Day RM. Peritumoural Delivery of Docetaxel-TIPS Microparticles for Prostate Cancer Adjuvant Therapy. Advanced Therapeutics 2020 October DOI: 10.1002/adtp.202000179
  • Chin MHW, Norman MDA,Gentleman E, Coppens M-O, Day RM. A Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues. ACS Applied Materials & Interfaces 2020 September https://dx.doi.org/10.1021/acsami.0c16478
  • Simitzi C, Vlahovic M, Georgiou A, Keskin-Erdogan Z, Miller J, Day RM. Modular Orthopaedic Tissue Engineering with Implantable Microcarriers and Canine Adipose-Derived Mesenchymal Stromal Cells. Frontiers in Bioengineering and Biotechnology 2020 July 22; 8(816): 1-15. https://doi.org/10.3389/fbioe.2020.00816
  • Hendow EK, Moazen M, Iacoviello F, Bozec L, Pellet-Many C, Day  RM. Microporous Biodegradable Films Promote Therapeutic Angiogenesis. Advanced Healthcare Care Materials. 2020 July 14; 9:1-10. https://doi.org/10.1002/adhm.202000806
  • Simitzi C, Hendow E, Li Z, Day RM. Promotion of Proangiogenic Secretome from Mesenchymal Stromal Cells via Hierarchically Structured Biodegradable Microcarriers. Advanced Biosystems 08 June 2020; 4(7): 1-13. doi.org/10.1002/adbi.202000062
  • Chin MHW, Gentleman E, Coppens MO, Day RM. Rethinking Cancer Immunotherapy by Embracing and Engineering Complexity. Trends Biotechnol. 2020 May 25:S0167-7799(20)30124-4. doi: 10.1016/j.tibtech.2020.05.003.
  • Nogueira JCF, Paliashvili K, Bradford A, Di Maggio F, Richards DA, Day RM, Chudasama V. Functionalised thermally induced phase separation (TIPS) microparticles enabled for "click" chemistry. Org Biomol Chem. 2020 Mar 25;18(12):2215-2218. doi: 10.1039/d0ob00106f.

Selected publications 2019

  • Paliashvili K, Di Maggio F, Ho HMK, Sathasivam S, Ahmed H, Day RM. A novel adjuvant drug-device combination tissue scaffold for radical prostatectomy. Drug Deliv. 2019 Dec;26(1):1115-1124. doi: 10.1080/10717544.2019.1686085
  • Syed O, Kim JH, Keskin-Erdogan Z, Day RM, El-Fiqi A, Kim HW, Knowles JC. (2019) SIS/aligned fibre scaffold designed to meet layered oesophageal tissue complexity and properties. Acta Biomater. 2019 Aug 22. pii: S1742-7061(19)30562-8. doi: 10.1016/j.actbio.2019.08.015.

Selected publications 2018

  • Culmer, P., Alazmani, A., Bryant, M.,… Day, R.M. (2018) Continence technologies whitepaper: Informing new engineering science research. Proc Inst Mech Eng H. 2018; Jun 1:954411918784073. doi: 10.1177/0954411918784073

Selected publications 2017

  • Sofokleous P, Ali S, Wilson P, Buanz A, Gaisford S, Mistry D, Fellows A, Day RM(2017)Sustained antimicrobial activity and reduced toxicity of oxidative biocides through biodegradable microparticles. Acta Biomater. 2017; S1742-7061(17)30617-7. doi: 10.1016/j.actbio.2017.10.001 
  • Omolu A, Bailly M, Day RM. (2017) Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity. Drug Deliv. 24(1):942-951. doi: 10.1080/
  • Liew LJ, Day RM, Dilley RJ. (2017) Tympanic membrane organ culture using cell culture well inserts engrafted with tympanic membrane tissue explants. Biotechniques. 1;62(3):109-114. doi: 10.2144/000114523.
  • Awwad S, Day RM, Khaw PT, Brocchini S, Fadda H. (2017) Sustained release ophthalmic dexamethasone: In vitro in vivo correlations derived from the PK-Eye. Int J Pharm. Feb 20. pii: S0378-5173(17)30137-0. doi: 10.1016/j.ijpharm.2017.02.047.

Selected publications 2016

  • Maini AA, George MJ, Motwani MP, Day RM, Gilroy DW, O'Brien AJ. (2016) A comparison of human neutrophils acquired from four experimental models of inflammation. PLoS ONE. 11 (10), doi:10.1371/journal.pone.0165502
  • Eriksson TM, Day RM, Fedele S, Salih VM. (2016) The regulation of bone turnover in ameloblastoma using an organotypic in vitro co-culture model. J. Tissue Eng. 6: 1-8. DOI: 10.1177/2041731416669629
  • Angelopoulos I, Southern P, Pankhurst QA, Day RM. (2016) Superparamagnetic Iron Oxide Nanoparticles Regulate Smooth Muscle Cell Phenotype. J Biomed Mater Res A. 104(10):2412-9 doi: 10.1002/jbm.a.35780
  • Hendow, E.K., Guhmann P., Wright, B., Sofokleous, P., Parmar, N., Day, R.M. (2016) Biomaterials for hollow organ tissue engineering. Fibrogenesis & Tissue Repair 9:3. doi: 10.1186/s13069-016-0040-6
  • Wright B, Emmanuel A, Athanasakos E, Parmar N, Parker G, Green B, Tailby E, Chandler H, Cushnie J, Pembroke J, Saruchera Y, Vashisht A, Day R. (2016) Women's views on autologous cell-based therapy for post-obstetric incontinence. Regen Med. 11(2):169-80. doi: 10.2217/rme.15.88
  • Malik, S. A., Ng, W. H., Bowen, J., Tang, J., Gomez, A., Kenyon, A. J., & Day, R. M. (2016). Electrospray synthesis and properties of hierarchically structured PLGA TIPS microspheres for use as controlled release technologies. Journal of Colloid and Interface Science, 467, 220-229. doi:10.1016/j.jcis.2016.01.021.

Selected publications 2015

  • Parmar, N., Day, R.M. (2015) TIPS to manipulate myogenesis: retention of myoblast differentiation capacity using microsphere culture. Eur Cell Mater. 30:41-50. doi: 10.22203/ecm.v030a04
  • Lakhkar, N. J., M Day, R., Kim, H. W., Ludka, K., Mordan, N. J., Salih, V., & Knowles, J. C. (2015). Titanium phosphate glass microcarriers induce enhanced osteogenic cell proliferation and human mesenchymal stem cell protein expression. Journal of tissue engineering, 6, 2041731415617741-?. doi:10.1177/2041731415617741
  • Wright, B., Parmar, N., Bozec, L., Aguayo, S.P., Day, R.M. (2015) A Simple and Robust Method for Pre-wetting Poly (lactic-co-glycolic) Acid Microspheres. Journal of Biomaterials Applications 30(2):147-59. doi: 10.1177/0885328215577297
  • Parmar, N., Ahmadi, R., Day, R.M. A novel method for differentiation of human mesenchymal stem cells into smooth muscle-like cells on clinically deliverable TIPS microparticles. (2015) Tissue Engineering Part C. 21(4):404-12. doi: 10.1089/ten.TEC.2014.0431

Selected publications 2014

  • Fullerton, J.N., Frodsham, G.C.M., Day, R.M. 3D printing: for the many, not the few (2014).  Nature Biotechnology 32:1086-87. doi:10.1038/nbt.3056
  • Parmar, N., Kumar, L., Emmanuel, A., Day, R. (2014). Regenerative medicine therapies for obstetric trauma-induced fecal incontinence. Regenerative Medicine 9(6), 831-40
  • Syed, O., Walters, N.J., Day, R.M., Hae-Won, K., Knowles, J.C. (2014) Evaluation of decellualrization protocols for production of tubular small intestine submucosa scaffolds for use in oesophageal tissue engineering. Acta Biomaterialia 10(12) 5043-5054. doi: 10.1016/j.actbio.2014.08.024
  • Parmar, N. & Day, R.M. Appropriately sized bioengineered human external anal sphincter constructs (2014).  Surgery 157(1):177-8. doi: 10.1016/j.surg.2014.05.025
  • Lau, W., Sofokleous, P., Day, R., Stride, E., Edirisinghe, M. A portable device for in situ deposition of bio-products (2014).  Bioinspired, Biomimetic and Nanobiomaterials. 3(2); 94-105. DOI:10.1680/bbn.13.00030.

    Selected publications 2013

    • Parmar N & Day R. (2013) 'Just can't wait: women's age-related incontinence'  in 'A Compendium of Essays: Has the Sisterhood forgotten older women?' Eds Sally-Marie Bamford & Jessica Watson; 2013 International Longevity Centre, London, UK.
    • Ghanbar, H., Luo, C., Bakhshi, P., Day, R., Edirisinghe, M. (2013) Preparation of Porous Microsphere-Scaffolds by Electrohydrodynamic Forming and Thermally Induced Phase Separation. Materials Science and Engineering C. 33:2488-98.
    • Riegler, J., Liew, A., Hynes, S., Ortega, D., O'Brien, T., Day, R., Richards, T., Sharif, F., Pankhurst, Q., Lythgoe, M. (2013) Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury. Biomaterials 34(8):1987-94.
    • Abou Neel, E., Bozec, L., Knowles, J. C., Syed, O., Mudera, V., Day, R., Hyun, J. K. (2012). Emerging Collagen Based Therapies Hit the Patient. Advanced Drug Delivery Reviews 65;429-456.
    • Rasekh, M., Ahmad, Z., Frangos, C., Bozec, L., Edirisinghe, M., Day, R. (2013). Spatial and temporal evaluation of cell attachment to printed polycaprolactone microfibres. Acta Biomaterialia 9(2):5052-62.

    Selected publications 2012

    • Gonzalez-Molina, J., Riegler, J., Southern, P., Ortega, D., Frangos, C., Angelopoulos, Y., Husain, S., Lythgoe, M., Pankhurst, Q., Day, R. (2012). Rapid magnetic cell delivery for large tubular bioengineered constructs. Journal of the Royal Society Interface 9(76):3008-16.

    Selected publications 2011

    • Ahmadi, R., Mordan, N., Forbes, A., Day, R. M. (2011). Enhanced attachment, growth and migration of smooth muscle cells on microcarriers produced using thermally induced phase separation. Acta Biomater 7(4), 1542-1549 doi: 10.1016/j.actbio.2010.12.022
    • Rasekh, M., Ahmad, Z., Day, R., Wickham, A., Edirisinghe, M. (2011). Direct Writing of Polycaprolactone Polymer for Potential Biomedical Engineering Applications. Advanced Biomaterials 13(9), B296-B305
    • Day, R. M. (2011). Functional Requirements of Wound Repair Biomaterials. In Farrar, D. (Ed.). Advanced Wound Repair Therapies ( pp.155-169). UK: Woodhead Publishing.


    Selected publications 2010

    • Foong, K. S., Patel, R., Forbes, A., Day, R. M. (2010). Anti-Tumor Necrosis Factor-Alpha-Loaded Microspheres as a Prospective Novel Treatment for Crohn's Disease Fistulae. Tissue Engineering 16(5):855-64 doi: 10.1089/ten.TEC.2009.0599
    • Keshaw, H., Foong, K. S., Forbes, A., Day, R. M. (2010). Perianal Fistulae in Crohn's Disease: Current and Future Approaches to Treatment. Inflammatory Bowel Diseases 16(5), 870-880.
    • Keshaw, H., Thapar, N., Burns, A. J., Knowles, J., Forbes, A., Day, R. M. (2010). Microporous collagen spheres produced via thermally induced phase separation for tissue regeneration. Acta Biomaterialia 6(3), 1158-1166.
    • Day, R. M. (2010). Alimentary Tract. In Attala, A., Lanza, R., Thomson, J., Nerem, R. (Eds.). Principles of Regenerative Medicine (2nd ed. pp.925-941). London, UK: Academic Press.

    Selected publications 2009

    • Keshaw, H., Georgiou, G., Blaker, J. J., Forbes, A., Knowles, J. C., Day, R. M. (2009). Assessment of Polymer/Bioactive Glass-Composite Microporous Spheres for Tissue Regeneration Applications. Tissue Engineering: Part A 15(7), 1451-1461. doi.org/10.1089/ten.tea.2008.0203
    • Moosvi, S. R., Day, R. (2009). Bioactive glass modulation of intestinal epithelial cell restitution. Acta Biomaterialia 5(1), 76-83.

    Selected publications 2008

    • Blaker, J. J., Knowles, J. C., Day, R. M. (2008). Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery. Acta Biomater. 4(2), 264-272. doi.org/10.1016/j.actbio.2007.09.011
    • Blaker, J. J., Pratten, J., Ready, D., Knowles, J. C., Forbes, A., Day, R. M. (2008). Assessment of antimicrobial microspheres as a prospective novel treatment targeted towards the repair of perianal fistulae. Aliment.Pharmacol.Ther. 28(5), 614-622. doi.org/10.1111/j.1365-2036.2008.03773.x