ADepT-PD: A placebo-controlled trial of escitalopram and nortriptyline for depressive symptoms in Parkinson’s, and to examine the effectiveness of nortriptyline to delay motor progression
12 January 2022
Funder: NIHR HTA
- Trial Information
The key aims of the ADepT-PD and ADepT-PD motor progression were to 1) establish the effectiveness of nortriptyline vs escitalopram vs placebo for depressive symptoms in PD (currently largely underrecognised) and 2) to examine the potential effects of nortriptyline to delay motor progression of Parkinson’s itself.
Many different types of antidepressants are available to treat depression in Parkinson’s but which one is the most suitable and effective for people with Parkinson’s is currently unclear. Escitalopram belongs to the most commonly prescribe group of medications for depressive symptoms, the SSRIs, but nortriptyline (a “tricyclic”) has also been suggested to be effective and well tolerated. In addition, there is some preclinical evidence that nortriptyline changes some of the disease processes in Parkinson’s disease. The trial was to examine how effective these treatments are for depressive symptoms in people with Parkinson’s, and also whether nortriptyline, is effective in delaying the slowing of movements associated with Parkinson’s.
The study involved assessments (face to face at study sites or remotely) before start of the trial medication, at 8 week, and then after 6 and 12 months.
The study is now closed to recruitment.
- NIHR HTA https://www.nihr.ac.uk/explore-nihr/funding-programmes/health-technology-assessment.htm
- Cure Parkinson’s Trust https://www.cureparkinsons.org.uk
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