UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


UCL Transgenic Service

The UCL Transgenic Service provides state of the art techniques and expertise in the creation, manipulation and delivery of genetically modified embryonic stem cell lines and mouse models.


The aim of the service is to help the scientific community with bespoke tools to better understand the molecular mechanism of mammalian genetics and development. The services provided may be tailored to suit each customer's needs. The service focuses on applying a 3R approach to all of the projects undertaken.

The UCL Transgenic Service facility provides the following services:

  • Cryopreservation
  • Rederivation/Cryorecovery
  • ES cell injection and targeting
  • TALEN microinjection
  • CRISPR/Cas9 microinjection and ES cell targeting
  • ES derivation
  • Morula aggregation