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Academic Vacancies

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Marie Curie Early Stage Researcher (PhD Studentship), - Ref:1864950 (D/L: 25/5/2020) 

UCL Department / Division

Chemistry

Location of position

London

Grade 

7

Hours

Full Time

Salary
(inclusive of London allowance)

£37,730 - £46,950 per annum ( MCT grade)

Duties and Responsibilities

Applications are invited for a 36-month PhD Studentship fully funded by the H2020 Marie Sklodowska-Curie Action and is available from June 2020. The successful candidate will be based in the Department of Chemistry at UCL and be registered as a PhD student at UCL to work with Dr Vijay Chudasama and Dr James Baker. The successful candidate will also go on secondments (lasting a few months) to different teams of the Targeted Anti-Cancer Therapies (TACT) Consortium.

Poor therapeutic efficacy and resistance are two major remaining challenges faced by conventional Antibody-Drug Conjugates (ADCs), a category of therapeutic that has classically been based on the attachment of a single type of cytotoxic drug to an antibody that targets an antigen that is highly over-expressed on certain cancer cells. A major hurdle in eliciting reliable and effective responses is the inter- and intra-heterogeneity of tumours. Most tumours contain highly diverse cell populations, including proliferating and non-proliferating cells.  Such widely diverse cell populations are often sensitive to different chemotherapeutics and a single cytotoxic agent is thus unlikely to produce a satisfactory response.

Our aim is to explore and solve this issue by using antibodies to selectively deliver pairs of mechanistically complementary drugs to cancer cells. The current objective is to compare the effects of using antibody targeting to deliver a combination of drugs versus classical single drug class ADCs. The student will contribute to the design, development and implementation of new chemical methods for antibody conjugation.

This is an exciting opportunity for a student with a strong chemistry background to tackle one of the biggest problems in science. A Chemistry-based degree with a strong knowledge of Organic Chemistry is an essential requisite, while some expertise in chemical biology or peptide chemistry is desirable. The successful candidate will join a group of highly motivated scientists (3 post-doctoral Research Associates, 9 PhD students and 3 MRes students) working at UCL to use organic chemistry to solve biological problems. The student will gain experience of direct collaboration within the EU Marie Sklodowska-Curie Innovative Training Network, which is a European Training Network offering the opportunity to motivated international Early Stage Researchers (ESRs) to address the tremendous challenge of developing next-generation Targeted Anti-Cancer Therapies by training a new generation of scientists to think big, but also to work methodically and logically alongside colleagues from academia and industry.

The starting date for the contract is expected to be 1st September 2020 or as soon as possible thereafter.

Key Requirements

The successful candidate must demonstrate eligibility according to the Marie Sklodowska-Curie Actions[1][1] eligibility requirements as an Early-Stage Researcher (ESR). At the date of recruitment[2][2], the candidate must be in the first four years (full-time equivalent research experience) of their research career and have not been awarded a doctoral degree. A Master degree (MSc or MChem) in Chemistry or related area as well as knowledge of modern research techniques in Organic Chemistry is essential.

[1][1] Guide for applicants Marie Sklodowska--Curie Actions Innovative Training Networks (ITN) 2018, at the link http://ec.europa.eu/research/participants/data/ref/h2020/other/guides_for_applicants/h2020-guide-appl-msca-itn_en.pdf

[2][2] The first day of employment of the Fellow for the purposes of the project (i.e. the starting date indicated in the employment /fellowship contract or equivalent direct contract).

The applicant can be of any nationality, but must not have resided or carried out their main activity (work, studies, etc.) in the UK for more than 12 months in the 3 years immediately prior to the date of recruitment[2][1].

[2][1] Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Further Details

Interested candidates are strongly advised, prior to applying, to read carefully the Job Description & Person Specification below.

Applicants should include a CV and cover letter clearly explaining their interest in the ESR position and in investigating the origins of life and outline their eligibility for the ESR position.

To apply please click here.

Informal inquiries can be directed to Dr Vijay Chudasama at v.chudasama@ucl.ac.uk. Any queries on the application process can be directed to Judith James at j.k.james@ucl.ac.uk, and hr.chem@ucl.ac.uk.

We particularly welcome female applicants and those from an ethnic minority, as they are under-represented within UCL at this level.

We will consider applications to work on a part-time, flexible and job share basis wherever possible.

Closing Date: 25th March

Job Description & Person Specification

Postgraduate Teaching Vacancies

Only available to UCL Chemistry Students - working a maximum of 20 hours per week. Work must not be carried out until we have seen and verified your Right to Work (i.e. passport). If you work before this, you will not be paid for any hours you did.

Postgraduate employment opportunities - Chemistry Department

Applications are invited from postgraduate students who wish to be considered for the following posts:

Postgraduate demonstrators Ad-Hoc work in the department

 

You should not carry out any work until we have seen and verified your right to work, any work carried out before this period will not be paid.

Payment will be at Grade 5 pt 17 on the UCL salary scale, which is currently £13.77 per hour (including London Allowance).

Successful applicants will be issued with an 'As and When' contract valid until for the duration of your degree registration.

If you wish to apply for Postgraduate teaching/demonstrating, please go to the PG Teaching Moodle page at: https://moodle.ucl.ac.uk/login/index.php   'Chemistry Teaching for PhD Students and PDRA's', then to 'Contracts and Training'

for further instructions. You can also email our HR Administrator, Ms Judith James from whom further details are available (Email: j.k.james@ucl.ac.uk).

In addition, you should send to Judith James a CV containing the following information:

1. Full name

2. Address

3. Date of birth

4. Academic Qualifications

5. National Insurance No. (if known)

6. Your Student registration number

7. Your areas of expertise

8. The name of your Supervisor

9. Month and year your postgraduate studies are due to finish if you complete and submit your thesis on time.

For Ad-hoc duties, arrangements will be made with UniTemps for payments to be processed, but again, they must see your Right to Work first before any work is done. Please contact Ms Judith James for guidance.

Please note, your Right to Work (i.e. passport) must be checked before you commence work. Please bring your passport to Judith, Nicola Phillips or Louise McSeveny for verification.

Applications are welcome at any time throughout the year but you cannot be considered for any paid employment within the department until you have applied and been accepted.

 

 

Postdoctoral Research Vacancies 

Research Fellow in Computational Materials Chemistry for Energy Materials, Ref: 1867329 (D/L: 4/6/2020)

UCL Department / Division

Chemistry

Location of Position

London

Grade

7

Hours

Full Time

Salary (inclusive of London Allowance)

£35,965 - £43,470 per annum

Duties and Responsibilities

Applications are invited for a Research Fellow to work in the group of Professor David O. Scanlon in the Department of Chemistry at University College London. The appointee will use advanced Computational Chemistry techniques to computationally predict and fully characterise a range of new Energy Materials.  A key principle of the research will be the full characterisation of these novel materials in terms of their electronic structure, dynamical stability, lattice thermal conductivity, and their full defect chemistry, allowing us to only put materials forward for experimental validation when their defect chemistry is suited to the application of choice.

The postholder will be required to carry out computational materials chemistry research focussed on understanding and predicting the properties of new Energy Materials, and specifically examining defects processes and heat transport in emerging materials. Computational work will be performed in collaboration with experimental efforts, and so the postholder will also present results and contribute significantly to an interdisciplinary feedback loop.

This position is funded by Innovate UK for 15 months in the first instance.

Key Requirements

The successful candidate will have a PhD degree (or about to be awarded a PhD) in Computational Materials Chemistry or relevant subject. Expertise in analysis of charged defects in solids using periodic density functional theory is essential. They will have a strong publication track record, a demonstrated commitment to excellence, and exceptional skills in computational chemistry. They will be expected to work in a highly multidisciplinary collaborative team, and have effective written and verbal communication skills in English.

Please note, appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (salary £31,479 - £33,194 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.

 

Further Details

A Job Description and Person Specification can be accessed at the bottom of this page. Please include a publication list along with CV.

To apply for the vacancy please click here.

Informal enquiries should be addressed to Professor David O. Scanlon (d.scanlon@ucl.ac.uk). Any queries on the application process can be directed to Judith James – j.k.james@ucl.ac.uk, as we wish to encourage online applications.

 

We particularly welcome female applicants and those from an ethnic minority, as they are under-represented within UCL at this level.

Closing date: 4 June 2020

Job Description & Person Specification

 

 

 

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