Magnetic Resonance Imaging (MRI) can be used to obtain detailed images of the inside the body.
It is largely unexplored with muscle and nerve, and we believe that it has the potential to revolutionise the diagnosis and monitoring of neuromuscular disease in the same way that MRI has transformed our understanding and treatment of multiple sclerosis.
For patient studies, a new Siemens
Trio (3 T) machine will become available.
We wish to use MRI technology to
measure patterns of neuromuscular disease in humans such as atrophy, signal change, oedema and fatty
degeneration of skeletal muscle as part of the primary disease or
secondary to nerve pathology.
We will extend these studies to directly investigate nerves, and we wish to find out whether MRI is a sensitive method of detecting therapeutic changes. Finally, we will use MRI to study nerve and muscle biopsies from patients and animals.