Disorders of the cardiovascular system and metabolism are the major cause of death and disability worldwide, and play a key role in the ageing process.
Since the 1970’s deaths from the commonest form of heart disease, coronary heart disease, have fallen dramatically but in recent years this decline has stalled and cardiovascular disease remains the second most common cause of death in the UK. In the future increasing life expectancy and the global epidemics of obesity, physical inactivity, and diabetes threaten to reverse favourable trends in cardiovascular disease.
Cardiometabolic Research at LHA covers the three major studies at LHA. The MRC National Survey of Health and Development (NSHD), the world's longest running birth cohort, the Southall and Brent Revisited (SABRE) study, a large tri-ethnic cohort originally recruited in 1988 in West London, and LINKAGE-Camden a study into Delirium and its effects on cognition and memory.
We aim to understand how factors acting over the life course, such as lifestyle factors, poor health in childhood and air pollution influence cardiovascular health, and how maintenance of cardiometabolic health throughout life contributes to healthy ageing.
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Park CM, Williams ED, Chaturvedi N, et al. Associations Between Left Ventricular Dysfunction and Brain Structure and Function: Findings From the SABRE (Southall and Brent Revisited) Study. J Am Heart Assoc. 2017 Apr 18;6(4). pii: e004898. doi: 10.1161/JAHA.116.004898.