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Thoracic and Molecular Pathology

Group Leader: Dr David Moore

Research focus

My research is focused on:

  • Preinvasive neoplastic disease in lung adenocarcinoma and the biological switching from an in situ to invasive phenotype in this disease. 
  • Tumours of the lung in the neuroendocrine spectrum and how genomic alterations correlate with phenotypic differences across this spectrum.
  • Characterising the immune infiltrate within primary non small cell lung cancer and metastatic disease sampled at post mortem. 

I am undertaking research within the field of molecular diagnostics, specifically the large scale retrospective analysis of next generation sequencing methods for somatic variant analysis.

Research Projects

  • I am actively involved in the TRACERx non small cell lung cancer project and the associated PEACE study at UCL. 
  • Leading projects evaluating NGS technologies and their use in routine molecular diagnostics through my work in the Sarah Cannon Molecular Diagnostics Laboratory.  

Selected Publications

  1. Moore DA, Saldanha GS, Ehdode A, Mughal MZ, Potter L, Dyall L, Pringle JH. Duplexratio tests as diagnostic biomarkers in malignant melanoma. Journal Molecular Diagnostics. 2015 Sep;17(5):616-22.
  2. Moore DA, Saldanha GS, Ehdode A, Potter L, Dyall L, Bury D, Pringle JH. Accurate detection of copy number changes in DNA extracted from formalin fixed paraffin embedded melanoma tissue using duplex ratio tests. Journal Molecular Diagnostics. 2013 Sep;15(5):687-94.
  3. Moore DA, Young CA, Morris HT, Oien KA, Lee JL, Jones JL, Salto-Tellez M. J Time for change: a new training programme for morpho-molecular pathologists? Clin Pathol. 2017 Nov 7.
  4. Moore DA, Le Quesne JP. The molecular approach to diagnosis in lung cancer. Br J Hosp Med (Lond). 2015 May;76(5):C74-6
  5. Moore DA, Howard Pringle J, Saldanha GS. Prognostic Tissue Markers in Melanoma. Histopathology. 2012 Apr;60(5):679-89
  6. Abbosh C*, Birkbak NJ*, Wilson GA*, Jamal-Hanjani M*, Constantin T*, Salari R*, Quesne JL*, Moore DA†, Veeriah S†, Rosenthal R, Marafioti T, Kirkizlar E, Watkins TBK, McGranahan N, et al. Phylogenetic ctDNA analysis depicts early stage lung cancer evolution. Phylogenetic ctDNA analysis depicts early stage lung cancer evolution. Nature. 2017 Apr 26. doi: 10.1038/ nature22364 (*joint first authors, †joint second authors).
  7. Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, Shafi S, Johnson DH, Mitter R, Rosenthal R, Salm M, Horswell S, Escudero M, Matthews N, Rowan A, Chambers T, Moore DA, et al. Tracking the Evolution of Non-Small-Cell Lung Cancer. N Engl J Med. 2017 Apr 26. doi: 10.1056/NEJMoa1616288

Support for career development awards/fellowships at the UCL Cancer Institute 

This procedure applies to internal and external candidates.

The UK has a flourishing landscape of Career Development Awards/Fellowships for talented junior scientists to set up their independent research laboratories. Theses include awards from UKRI, ERC, the Welcome Trust, Cancer Research UK, the Royal Society and many other organisations.

The UCL Cancer Institute has been very successful in supporting scientists for such awards, providing a welcoming environment, extensive help for preparation of proposals, mock interviews and administrative support. Many of our fellows have also gone on to tenured positions. 

If you are interested in exploring the Cancer Institute and UCL as your Host Institution, please submit a copy of your CV, a summary of future plans, and a brief explanation of why you would like to be hosted at the Cancer Institute during your early career award/fellowship to CI.ECRhost.enquiries@ucl.ac.uk at least 3 months before the application deadline of granting bodies.

A selection committee, made up of at least three representatives with appropriate expertise within the Institute will review and discuss your proposal and make a recommendation as to whether the applicant is shortlisted. Shortlisted applicants will be invited to visit the Cancer Institute for a presentation to Faculty, with practical details to be provided at the time of shortlisting. 

World Cancer Day 2023