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UCL Cancer Institute

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Further research highlights

    • Together with our colleagues, we proposed the now universally accepted classification and nomenclature of the PI3K isoforms [1, 2]
    • We have reviewed the PI3K field on numerous occasions (see amongst others: [2-11])
    • Prof Bart Vanhaesebroeck and Dr Ralitsa Madsen recently published the Science Signalling review "Cracking the context-specific PI3K signalling code", outlining what they see as the key challenges and opportunities in the fourth decade of PI3K signalling research. For free reprinting, please follow the link  http://stke.sciencemag.org/cgi/content/full/sigtrans;13/613/eaay2940?ijkey=RGYpVBG2d87oE&keytype=ref&siteid=sigtrans
    • Together with Dr. Pedro Cutillas at Queen Mary University of London, we set up Activiomics Ltd. (2010) to develop biomarkers in disease using mass spectrometry techniques. In March 2014, Activiomics was acquired by Retroscreen Virology (now hVIVO).

     References

    1. Zvelebil, M.J., et al., Structural and functional diversity of phosphoinositide 3-kinases. Philos Trans R Soc Lond B Biol Sci, 1996. 351(1336): p. 217-23.
    2. Vanhaesebroeck, B., et al., Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci, 1997. 22(7): p. 267-72.
    3. Vanhaesebroeck, B. and Alessi, D.R., The PI3K-PDK1 connection: more than just a road to PKB. Biochem J, 2000. 346 Pt 3: p. 561-76.
    4. Vanhaesebroeck, B., et al., Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem, 2001. 70: p. 535-602.
    5. Okkenhaug, K. and Vanhaesebroeck, B., PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol, 2003. 3(4): p. 317-30.
    6. Vanhaesebroeck, B., et al., Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci, 2005. 30(4): p. 194-204.
    7. Okkenhaug, K., Ali, K. and Vanhaesebroeck, B., Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K. Trends Immunol, 2007. 28(2): p. 80-7.
    8. Kok, K., Geering, B. and Vanhaesebroeck, B., Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem Sci, 2009. 34(3): p. 115-27.
    9. Vanhaesebroeck, B., et al., The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol, 2010. 11(5): p. 329-41.
    10. Vanhaesebroeck, B., Stephens, L., and Hawkins, P., PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol, 2012. 13(3): p. 195-203.
    11. Vanhaesebroeck, B., Whitehead, M.A. and Piñeiro, R., Molecules in medicine mini-review: isoforms of PI3K in biology and disease. J Mol Med, 2016.