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UCL Cancer Institute

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Pathology Translational Technology Platform

The Pathology Translational Technology Platform provides a wide range of tissue-based and molecular services to research scientists within the UCL Cancer Institute and throughout UCL.

The laboratory is well equipped to perform all experimental tissue-based procedures on human and non-human samples, and to provide molecular biology services on a project-specific level to investigators operating on variety of tissues (fresh/frozen or FFPE), body fluids and cells in culture.

As part of the Pathology Research Department at the UCL Cancer Institute, we are based at the Rockefeller Building in UCL's Bloomsbury Campus. 


Services

  • Automated tissue processing & embedding to wax
  • Section cutting for Haematoxylin-Eosin (H&E) and Immunohistochemistry (IHC)
  • Fresh Frozen processing & sectioning
  • Antibody optimization and Immunohistochemistry (IHC)
  • RNAscope
  • Tissue Micro Arrays (TMA) construction
  • Optimised DNA extraction from FF, FFPE & blood, including: PCR / qPCR
  • RNA extraction from FF, FFPE & blood, including: RT-qPCR
  • DNA & RNA QC - Nanodrop / Qubit / Tapestation / qPCR

Booking

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Equipment

Excelsior AS tissue processor

The Thermo Scientific Excelsior AS is an enclosed automated tissue processor. It is used for the fixation, dehydration, clearing and infiltration of pathology specimens prior to embedding and sectioning.

Excelsior AS tissue processor

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Embedding station

The tissue embedding station is a complete system designed for embedding tissue in paraffin blocks.

Leica Embedding Station

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Microtome

The microtome is a mechanical device used to cut biological specimens into very thin sections for detailed microscopic examination.

Microtome RM2235

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Cryostat

The cryostat is used for sectioning fresh frozen unfixed tissue.

Cryostat

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Tissue Arrayer

The manual Tissue Arrayer enables the construction of Tissue MicroArrays (TMA) from formalin-fixed, paraffin-embedded normal and tumor tissues, cell lines, xenographs and samples from transgenic animals.

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Covaris E220e Sonicator

Covaris E220e Sonicator enables sample prep for a variety of application areas including DNA shearing for Next-Gen sequencing, RNA extraction, tissue disruption and homogenization, Chromatin shearing, cell lysis and compound formulation.

Covaris E220

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Chemagic Prepito Instrument

Chemagic Prepito Instrument allows the isolation of high yield pure DNA/RNA for sensitive downstream applications incuding NGS, MLPA, Genotyping, Chip Based Applications.

Chemagic Prepito

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Qubit 3.0 Fluorimeter

The Qubit® 3.0 Fluorometer accurately measures DNA, RNA, and protein by using a highly sensitive fluorogenic dye that emits signals only when bound to specific target molecules.

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Tapestation 2200

The 2200 TapeStation enables the rapid characterisation of DNA or RNA samples quality control in next-generation sequencing (NGS), microrarray and qPCR workflows.

Tapestation 2200

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Nanodrop 1000

The NanoDrop is a full-spectrum, UV-Vis spectrophotometers used to quantify and assess purity of DNA, RNA, Protein and more.

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SimpliAmp Thermocycler

The SimpliAmp Thermalcycler is designed to perform routine PCR experiments.

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QuantStudio 3 qPCR

The QuantStudio 3 Real-Time PCR System is design to perform quantitative real-time PCR experiments.

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Eppendorf Concentrator Plus

The Eppendorf Concentrator Plus enables quick and gentle vacuum concentration of DNA/RNA, nucleotides, proteins and other liquid or wet samples.

Gemini AS Automated Slide Stainer

The Automated H&E stainer enables the simultaneous staining of various slide racks with different staining protocols (haematoxylin & eosin and special staining).

Gemini AS Automated Slide Stainer

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