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UCL Division of Biosciences

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Professor Patricia Salinas

Professor Patricia Salinas

Professor of Cellular Neurobiology

Cell & Developmental Biology

Div of Biosciences

Joined UCL
1st Jan 2004

Research summary

My laboratory has been studying how neuronal networks are generated during development and the mechanisms involved in the complex pattern of axon guidance, dendritic arborization and synapse formation in the vertebrate nervous system. We are particularly interested in understanding the role and the mechanisms of action of Wnt proteins in the terminal remodelling of axons during the initial stages of synaptic contact and in the mechanisms by which Wnts proteins stimulate synaptic assembly. My lab has discovered that Wnt signalling modulates neuronal connectivity by regulating axon behaviour, dendrite morphogenesis and central synaptogenesis. Further work is aimed at elucidating how Wnt proteins regulate the axonal cytoskeleton in developing neurons to convert actively growing growth cones into synaptic boutons and how Wnts stimulate the assembly and maintenance of synapses. Other projects in the lab include the role of Wnt signalling in neurotransmitter release and circuit modulation in the adult brain..

Education

Oregon Health and Science University
PhD, Microbiology | 1989
Universidad Nacional de Tucuman
BSc, Clinical Biochemistry | 1981
Publications