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Prof Matilda Katan

Prof Matilda Katan

Professor of Protein Biochemistry

Structural & Molecular Biology

Div of Biosciences

Joined UCL
1st Oct 2011

Research summary

The aim of our current research is to obtain and use structural and mechanistic insights into cell signalling proteins and, together with mapping their network connectivity, understand their biological functions and deregulation in disease. We are also moving this fundamental research forward towards drug discovery. We cover several key cell signalling components: tyrosine kinase receptors (FGFR), phosphoinosite-signalling enzymes (PLC), small GTPases from Ras and Rho families and novel enzymes involved in posttranslational modifications.  Deregulation of these cellular components has been linked to a number of diseases, notably, to different types of cancer and to immune disorders.

Experimentally, our programme combines structural biology, cellular systems biology and animal work. Our multidisciplinary approaches are further expanded through collaborations within and outside UCL.

Main Funding

CRUK, MRC and AstraZeneca

Teaching summary

Teaching involves:

Tutorials for Principals and Practice of Experimental Biochemistry (BIOC1007) and Biomolecular Structure and Function (BIOC2004).

Organisation and lectures for Cancer Biology Module (BIOC3013).

Education

University of Glasgow
Doctorate, Doctor of Philosophy | 1985
Other higher degree, Bachelor of Science and Master of Science | 1981

Biography

Following a completion of PhD in Biochemistry at Glasgow University, further scientific career was in cancer research at dedicated institutes in London, Imperial Cancer research Fund, Ludwig Institute for Cancer research and Institute of Cancer Research. This research area remains the focus of current work at ISMB.

Publications