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UCL Division of Biosciences

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Mendelian randomization analyses implicate biogenesis of translation machinery in human aging

27 April 2022

javidnia_2022

Here, we use casual inference approaches in genetic epidemiology to investigate whether adult, tissue-specific biogenesis of translation machinery drives human aging. 

Our study shows the utility of leveraging genetic variation in expression to elucidate how essential cellular processes impact human aging. The findings extend the evolutionary conservation of protein synthesis as a critical process that drives animal aging to include humans.

Mendelian randomization analyses implicate biogenesis of translation machinery in human aging (cshlp.org)