Bähler lab show Amino acids whose intracellular levels change during ageing alter lifespan of yeast
17 November 2020
Amino acids whose intracellular levels change during aging alter the lifespan of yeast. Our results raise the possibility that certain amino acids are biomarkers of aging, and their concentrations can modulate cellular lifespan.
Amino acid deprivation or supplementation can affect cellular and organismal life span, but we know little about the role of concentration changes in free, intracellular amino acids during aging.
The latest research from the Bähler Lab (UCL Institute of Healthy Ageing) determines free amino acid levels during chronological aging of nondividing fission yeast cells. Their research compared wild-type with long-lived mutant cells that lack the Pka1 protein of the protein kinase A signalling pathway. In wild-type cells, total amino acid levels decrease during aging, but much less so in pka1 mutants. Two amino acids strongly change as a function of age: glutamine decreases, especially in wild-type cells, while aspartate increases, especially in pka1 mutants. Supplementation of glutamine is sufficient to extend the chronological life span of wild-type but not of pka1Δ cells. Supplementation of aspartate, on the other hand, shortens the life span of a1Δ but not of wild-type cells.
The results of their study raises the possibility that certain amino acids are biomarkers of aging, and their concentrations during aging can promote or limit cellular life span.