UCL Division of Biosciences


Congratulations to Alic lab – new paper in Cell Reports

12 February 2020

The latest publication from the Alic Lab (IHA) is now out in Cell reports.


We found that reduced activity of RNA polymerase I extends healthy lifespan in Drosophila. This lifespan extension can be recapitulated by silencing Pol I exclusively in the cell-types of the adult midgut. Reducing Pol I activity improves multiple aspects of organismal health, delaying age-related decline in neuromuscular function and preventing age-related gut hyperplasia. See the open access article in full at: https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30026-7?