UCL Division of Biosciences


CDB Seminar - Dr Susana Lima

09 May 2024, 1:00 pm–2:00 pm

photo of Susana Lima

Title: ‘Should I mate or should I go: cyclical control of female rejection behaviour.’

This event is free.

Event Information

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Michael Wright – Cell and Developmental Biology

Abstract: Cyclic fluctuations in sex hormone levels intricately coordinate female sexual behavior with reproductive capacity, notably demonstrated in rodents where females only accept copulation attempts during their fertile phase. Outside this window, copulation is not only hindered by low receptivity but also actively rejected. Despite extensive research on female receptivity, rejection behavior has been largely overlooked, often dismissed as a lack of receptivity. Here I will describe a novel circuit dedicated to the cyclical control of rejection behavior situated in the ventromedial hypothalamus. Our findings suggest that a female's sexual response to copulation attempts throughout the reproductive cycle arises from two distinct processes: receptivity and rejection. These processes are governed by separate and spatially segregated hypothalamic populations, whose activity is modulated by the reproductive cycle in a bidirectional and opposing manner.

Zoom: https://ucl.zoom.us/j/96976298164?pwd=ZTRpS2pRMVpUU1U5U0ZFVXM4ZDJPQT09

Host: Arantza Barrios

About the Speaker

Dr Susana Lima

at Champalimaud Centre

More about Dr Susana Lima