CCMN Lecture Series: Giuseppe Gangarossa, Université Paris Cité
30 May 2024, 2:00 pm–3:00 pm
Title: 'The paraventricular thalamus: a new player in the control of feeding behaviours and energy balance'
This event is free.
Event Information
Open to
- All
Availability
- Yes
Cost
- Free
Organiser
-
Anna Roberts – UCL, Neuroscience, Physiology, Pharmacology
Location
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Medawar, G01Lankester Lecture TheatreGower StreetLondonWC1E 6BTUnited Kingdom
Abstract: The paraventricular thalamus (PVT) has recently emerged as a critical hub involved in the regulation of cognitive processes but also in the integration of homeostatic and visceral signals, thus controlling adaptive and food-seeking behavioural responses. However, despite growing evidence, the neural mechanisms by which the PVT gates feeding, energy balance and nutrients partitioning remain largely unknown.
Here, we show that catecholaminergic projections from the hindbrain to the PVT and a specific subpopulation of PVT-neurons, notably those expressing the dopamine D2 receptors, promptly and bidirectionally gate feeding behaviours, body homeostasis and energy balance, thereby contributing to the control of energy-related adaptive responses in both physiological and obesogenic contexts. In addition, by combining complementary cutting-edge strategies (cell-type specific chemogenetics, ex vivo and in vivo neuronal dynamics) to functional behavioural and metabolic readouts, we describe PVTD2R-neurons as gatekeepers of hunger and satiety.
These results may lead to a new understanding of unconventional brain circuits involved in food-related disorders and may provide new therapeutic solutions to counterbalance obesity-associated dysfunctions.
About the Speaker
Giuseppe Gangarossa
Professor at the Faculty of Sciences at Université Paris Cité
More about Giuseppe Gangarossa