CDB Seminar - Prof Rosa Cossart, INSERM Aix-Marseille University

Zoom: https://ucl.zoom.us/j/95846148915

Talk abstract: The hippocampus supports navigation in the real world and across events of our lives. This is supported by cognitive maps relying on two forms of representation, one that is map-based or allocentric and anchored in the external world (external representation) and the other that is self-referenced or egocentric (internal representation), and requires body movement. Work from our lab and others indicate that the circuits contributing to the balance between external and internal representations in the hippocampus would be partly predetermined by developmental programs.  However, during the perinatal period, the developing hippocampus is mainly driven by bottom-up external environmental and body-derived signals. This presentation aims to unravel the emergence of functional hippocampal circuits over the course of development. Through a synthesis of published and unpublished data, we highlight the dual influence of early developmental programming and ongoing interaction with sensory signals.

Suggested references:

• Cossart, R., and Khazipov, R. How development sculpts hippocampal circuits and function. Physiol Rev 102, 343–378. https://doi.org/10.1152/physrev.00044.2020. (2022).
• Dard et al. https://doi.org/10.7554/elife.78116. (2022)
• Leprince et al. https://doi.org/10.1101/2022.06.03.494656. (2022)
• Malvache A*, Reichinnek S*, Villette V*, et al Science, 353(6305):1280-3. (2016)

Host: Laurenz Muessig l.mussig@ucl.ac.uk