UCL Division of Biosciences


POSTPONED GEE Seminar - Professor Aoife Mc Lysaght, Trinity College Dublin

11 October 2023, 12:00 pm–1:00 pm

Title: 'Polyploidy and Rediploidisation in Stressful Times'

Event Information

Open to

UCL staff | UCL students | UCL alumni




Amy Godfrey


Malet Place Engineering Building

Academic Host: Adam Rutherford
Abstract: Whole genome duplication (polyploidy) is a rare but dramatic genomic upheaval that has been credited with creating the conditions for great evolutionary innovation and adaptation, most famously around the origin of vertebrates. The possible short- and long-term benefits of polyploidy are hotly-debated, and one increasingly popular hypothesis links genome duplication to adaptive benefits during dramatic environmental upheavals that are responsible for otherwise mass extinctions. Some of our recent work showed that the complex nature of rediploidisation masked a shared polyploidy in the sturgeon and paddlefish lineages, thus revising the date backwards in time to a period coinciding with the Triassic-Jurassic mass extinction. Furthermore, we have directly tested the immediate effects of polyploidy in an animal for the first time, comparing diploid and neotetraploid C. elegans under regular and stressful conditions, revealing a clear advantage for tetraploids in stress resilience.


About the Speaker

Professor Aoife Mc Lysaght

Head of the Genetics Department at Trinity College Dublin

More about Professor Aoife Mc Lysaght