UCL Division of Biosciences


CDB Seminar - Dr M. Lisa Manning, Syracuse University

19 October 2023, 1:00 pm–2:00 pm

photo of dr m lisa manning

Title: Predicting mechanics of 3D epithelia in vertebrate embryonic development

This event is free.

Event Information

Open to







Michael Wright – Cell and Developmental Biology

Talk abstract: In vertebrates, the formation and maintenance of complex three-dimensional shapes in epithelia drives several important developmental processes. In addition, a collection of recent discoveries both in vivo and in vitro suggests that the collective mechanical response of a tissue (its fluidity or rheology) helps to control morphogenetic events.  Therefore, there is a need to develop fully 3D biophysical models for epithelia that can predict or validate how global tissue mechanics impacts the structure and function of epithelia. In this talk, I will discuss several recent projects by our group and others to develop such models for specific model systems, including the left-right organizer in zebrafish and stratification and placode formation in mouse skin, where there are interesting interactions between cell shapes, epithelial architecture, and tissue fluidity. I will highlight how an interplay between models and experiments can help to drive a better mechanistic understanding of the processes that drive 3D tissue structure and function, especially when multiple mechanisms are operating at the same time.

Suggested references:

Clémentine Villeneuve, Ali Hashmi#, Irene Ylivinkka#, Elizabeth Lawson-Keister#, Yekaterina A. Miroshnikova, Carlos Pérez-González, Bhagwan Yadav, Tao Zhang, Danijela Matic Vignjevic, Marja L. Mikkola, M. Lisa Manning* and Sara A. Wickström*.(2022). Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture, submitted, BioRXiv https://www.biorxiv.org/content/10.1101/2022.12.12.519937v1.

Paula C. Sanematsu, Gonca Erdemci-Tandogan, Himani Patel, Emma M. Retzlaff, Jeffrey D. Amack, M. Lisa Manning. “3D viscoelastic drag forces drive changes to cell shapes during organogenesis in the zebrafish embryo,” special inaugural issue of Cells and Development, https://doi.org/10.1016/j.cdev.2021.203718 BioRXiv https://doi.org/10.1101/2021.02.23.432503 (2021)

Zoom: https://ucl.zoom.us/j/95624077501

Host: Dr Alessandro Mongera

About the Speaker

Dr M Lisa Manning

William R. Kenan, Jr. Professor of Physics at Syracuse University


  • Defects and deformation in disordered solids and glasses.
  • Surface tension and emergent mechanical properties in developing embryonic tissues.
  • Mitotic waves and pattern formation in biological tissues.
  • Constitutive models for friction and shear banding.
More about Dr M Lisa Manning