UCL Division of Biosciences


CDB Seminar - Prof Sarah-Maria Fendt, VIB KU Leuven Center for Cancer Biology

30 November 2023, 12:00 pm–1:00 pm

Photo of Sarah-Maria Fendt

Title: Metabolic Rewiring Driving Metastasis Formation

This event is free.

Event Information

Open to







Michael Wright – Cell and Developmental Biology

Talk abstract: Metastasis formation is the leading cause of death in cancer patients. We find that metabolic rewiring is a liability of metastasizing cancer cells. For example, we discovered that extracellular remodeling of the metastatic niche, a process essential to metastasis formation, requires a transcriptional-independent regulation via the metabolites. Moreover, we provide knowledge on intratumor heterogeneity of metabolism and its role in pre-metastatic niche and metastasis formation. Thus, we study the metabolism of metastasizing cancer cells with the goal to define novel therapeutic strategies.

Suggested reference: Bergers & Fendt Nat Cancer Rev 2021

Host: Tanushree Kundu

Zoom link: https://ucl.zoom.us/j/96687030152

About the Speaker

Prof Sarah-Maria Fendt

Head of the Laboratory of Cellular Metabolism and Metabolic Regulation at KU Leuven, Belgium

Sarah-Maria Fendt is since 2013 a Principal Investigator at the VIB Center for Cancer Biology and Professor of Oncology at KU Leuven, Belgium. Sarah’s lab is specifically interested in elucidating general regulatory principles in metabolism, and understanding cancer metabolism during metastasis formation as well as during altered whole body physiology. To perform novel research in her fields of interest her group exploits their expertise in metabolomics and fluxomics. The research of Sarah’s lab is currently funded by multiple (inter)national grants and industry, which include an ERC consolidator grant. Sarah received several awards such as the EMBO Gold Medal. 

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