UCL Division of Biosciences


NPP Seminar - Distinguished Professor David Kleinfeld, UCSD

22 February 2023, 1:00 pm–2:00 pm

David Kleinfeld

Title: Coupled arteriole oscillations in the brain and what they tell about neuronal activity

Event Information

Open to

UCL staff | UCL students | UCL alumni




Charlette Bent-Gayle


131 A V Hill
Medical Sciences and Anatomy
Gower Street
United Kingdom

Academic Host: Angus Silver

Abstract: Pial arterioles form an interconnected network that distribute blood across the cortical mantle and source nourishment to brain cells. Far from a passive network, the diameter of these arterioles intrinsically oscillate in the ~ 0.1 Hz vasomotor band. The pial arterioles integrate activity from neighboring arterioles, underlying neurons, and subcortical nuclei to produce space-time patterns of coherent oscillations. I will discuss optical and MR experiments and their analysis that seek to understand these patterns and exploit them to infer neuronal activity

About the Speaker

Distinguished Professor David Kleinfeld

at UCSanDiego

David Kleinfeld received his Ph.D. from UCSD and was a Member of Technical Staff at the former AT&T Bell Laboratories prior to joining the faculty at UCSD. He is a recipient of a David and Lucile Packard Foundation Interdisciplinary Science Award, a NIH Directors Pioneer Award, a NINDS Research Program Award, and currently holds the Experimental Biophysics Endowed Chair through Physics. David is a fellow of the American Association for the Advancement of Science and a member of the American Academy of Arts and Sciences. He currently leads the Specialization on Computational Neuroscience through the Neurosciences Graduate Program.

More about Distinguished Professor David Kleinfeld