CCMN Lecture Series: Professor David Hodson
14 December 2023, 1:00 pm–2:00 pm
Title: ‘Visualizing and interrogating GLP1R and GIPR signalling from the single molecule to the whole organism’
This event is free.
Cruciform, Lecture Theatre 2Cruciform BuildingGower StreetLondonWC1E 6BTUnited Kingdom
Abstract: Glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) have emerged as major drug targets for the treatment of type 2 diabetes and obesity . For example, drugs that target GLP1R and/or GIPR show profound effects on glucose levels and food intake. Despite this, we still have limited knowledge of where GLP1R and GIPR are expressed in the body, which is holding back development of even more effective drugs. In the current presentation, I will introduce new technologies to visualize and interrogate GLP1R and GIPR expression with single cell and single molecule resolution. I will also discuss how these studies have led to new understanding of GLP1R and GIPR biology, with relevance for type 2 diabetes and obesity therapy, as well as ongoing clinical trials on neurodegenerative and inflammatory disease.
About the Speaker
Professor David Hodson
Robert Turner Professor of Diabetic Medicine at University of Oxford
David trained as a Veterinary Surgeon at the University of Bristol before commencing PhD studies on the seasonal regulation of fertility with Dr Domingo Tortonese. Following postdoctoral studies on the hypothalamo-pituitary axis with Dr Patrice Mollard at the Institut de Génomique Fonctionnelle in Montpellier, France, David moved to Imperial College London where he set up a group devoted to diabetes research. In 2016, David joined the Institute of Metabolism and Systems Research at the University of Birmingham where he leads the Islet Biology Group. Most recently, the lab has moved to the Oxford Centre for Diabetes, Endocrinology and Metabolism at the University of Oxford. The major aims of the group are to develop novel tools and imaging approaches to understand how alpha, beta and delta cells, which reside within the islet, release hormone to maintain normal glucose levels during health and disease.More about Professor David Hodson