UCL Division of Biosciences


GEE Friday Seminar - Dr Alex Hull, Postdoctoral Research Associate, IHA

28 January 2022, 3:00 pm–4:00 pm

Title: 'Microbiota Dysbiosis Causes Immune Activation and Pathology in a Drosophila Lysosomal Storage Disease Model'

Event Information

Open to

UCL staff | UCL students | UCL alumni




GEE Friday Seminars Organising Committee



Abstract: Lysosomal storage diseases (LSD) are a rare class of heritable metabolic disorders with multi-organ defects and few therapeutic strategies, and several causative LSD genes are risk factors for Parkinson's. We establish a Drosophila disease model with shortened lifespan, loss of autophagic flux in the brain and neurological defects and demonstrate constitutively high systemic immune activation. We evidence an altered microbiome, and remarkably raising the flies in germ-free conditions ameliorates pathology and eliminates the immune response. 


About the Speaker

Dr Alex Hull

Postdoctoral Research Associate at UCL

Alex graduated with a 1st class BSc in Genetics from the University of Liverpool. He then completed his PhD in the research group of Dr Herman Wijnen at the University of Southampton, studying the developmental role of CLK/CYC in adult Drosophila circadian rhythms. Alex has just returned from the US where he was a post-doc at the Fred Hutchinson Cancer Research Centre in Seattle.

More about Dr Alex Hull