UGI Seminar - Dr Ville Pimmenoff - Karolinksa Instituet

Abstract:   Comprehensive human papillomavirus (HPV) vaccine implementation will radically change the ecological conditions of this virus-host interaction. Vaccinated early adolescent now possess a sustainable protective immune response. Furthermore, depending on the community level vaccination coverage and cross-protection strategy the unvaccinated females and males will be protected by strong, vague or no herd effect against a number of oncogenic HPV type infections. Vaccine-induced evolutionary responses of different HPV types warrant examination. In my talk I will discuss the evolutionary framework and results on the occurrence of non-vaccine HPV types over-time up to nine years post-vaccination in a community-randomized setting with gender-neutral and/or girls-only HPV vaccination strategy vs. no HPV vaccination.