NPP Seminar: Prof Riccardo Olcese, University of California Los Angeles
16 November 2021, 4:00 pm–5:00 pm
![Prof Riccardo Olcese](https://www.ucl.ac.uk/biosciences/sites/biosciences/files/styles/large_image/public/events/riccardo_olcese_1.jpg?itok=mY9dBS3f)
“The Voltage Sensors of Skeletal Muscle Contraction"
This event is free.
Event Information
Open to
- All
Availability
- Yes
Cost
- Free
Organiser
-
Charlette Bent-Gayle
Abstract: Initiation of skeletal muscle contraction is triggered by rapid activation of RyR1 channels in response to sarcolemmal depolarization. RyR1 is an intracellular channel and has no voltage-sensing structures, but it is coupled with the voltage-sensing apparatus of CaV1.1 channels to inherit voltage sensitivity. Using an opto-electrophysiological approach, the Olcese laboratory at the University of California Los Angeles studies the excitation-driven molecular events controlling both CaV1.1 pore opening and RyR1 activation. Each of the four CaV1.1 voltage-sensing domains exhibits unique biophysical properties in terms of kinetics and voltage dependence, providing a rationale for how CaV1.1, a slowly-activating channel, can trigger the rapid activation of RyR1.
Zoom: Click here
Meeting ID: 929 8555 3708
Passcode: 119860
Hosts: Ivan Kadurin and Annette Dolphin
The Neuroscience, Physiology and Pharmacology (NPP) Seminar Series in partnership with The Physiological Society.
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![npp](https://www.ucl.ac.uk/biosciences/sites/biosciences/files/styles/small_image/public/picture1_0.jpg?itok=sMK22WiL)
About the Speaker
Riccardo Olcese
Professor of Anesthesiology and Physiology at University of California Los Angeles
More about Riccardo Olcese