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Cell and Developmental Biology

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Professor Patricia Salinas

Professor Patricia Salinas

Address

339 (4th floor)
Department of Cell and Developmental Biology
Laboratory for Molecular and Cellular Biology (LMCB)
London
WC1E 6BT

Appointments

  • Professor of Cellular Neurobiology
    Cell & Developmental Biology
    Div of Biosciences

Joined UCL

2004-01-01

My laboratory has been studying how neuronal networks are generated during development and the mechanisms involved in the complex pattern of axon guidance, dendritic arborization and synapse formation in the vertebrate nervous system. We are particularly interested in understanding the role and the mechanisms of action of Wnt proteins in the terminal remodelling of axons during the initial stages of synaptic contact and in the mechanisms by which Wnts proteins stimulate synaptic assembly. My lab has discovered that Wnt signalling modulates neuronal connectivity by regulating axon behaviour, dendrite morphogenesis and central synaptogenesis. Further work is aimed at elucidating how Wnt proteins regulate the axonal cytoskeleton in developing neurons to convert actively growing growth cones into synaptic boutons and how Wnts stimulate the assembly and maintenance of synapses. Other projects in the lab include the role of Wnt signalling in neurotransmitter release and circuit modulation in the adult brain..
Award year Qualification Institution
1989 PhD
Doctor of Philosophy
Microbiology
Oregon Health and Science University
1981 BSc
Bachelor of Science
Clinical Biochemistry
Universidad Nacional de Tucuman

Collaborators

Keywords

Alzheimer's disease|*|Axon guidance|*|Axonal transport|*|Brain slice physiology|*|Cell culture|*|Confocal microscopy|*|Dendrite|*|Development|*|Electron Microscopy|*|Electrophysiological recording techniques|*|Fluorescence microscopy techniques|*|Gene expression|*|Genetic manipulation (including knockout/knockin)|*|Growth cone|*|Hippocampus|*|Image analysis|*|Imaging|*|Immunohistochemistry|*|Mouse|*|Multi-photon imaging|*|Neural Circuits/Networks|*|Neural signalling|*|Neurodegeneration|*|Neuromuscular junction|*|Neuron|*|Neuronal circuit assembly and modulation|*|Parkinson's disease|*|Patch-clamp recording|*|Protein transport/localisation|*|Signalling|*|Synaptic plasticity|*|Time-lapse imaging|*|Transgenic mice
  •  Salinas Lab