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A list of current and past research projects, all of which are collaborations with industrial partners
- 2020/2021
Project title Researcher Supervisor(s)/Industrial Partner 3D measurement of fouling in membrane filtration: towards model based investigation and design
Piotr Kucia
Prof Daniel Bracewell & Dr Thomas Johnson
PALL
Design and characterisation of a scale down perfusion platform for mammalian cell process development
Ciara Lucas
Prof Martina Miceletti & Dr Andrea Rayat
PALL
Nanofibre adsorbent design informed by mechanistic modelling of bioprocess performance
Gyorgy Ovari
Prof Daniel Bracewell & Dr Stephen Goldrick
Cytiva
Scalable production of bioengineered fur products
Matt Wasmuth
Dr Darren Nesbeth & Dr Kenth Gustafsson
Furoid
- 2019/2012
Project title Researcher Supervisor(s)/Industrial Partner Big data analytics streamlining therapeutic drug development from micro-scale through to industrial-scale Haneen Alosert Professor Suzanne Farid and Dr Stephen Goldrick Understanding the impact of shear stresses on different cell lines in the Allegro STR system Jordan Delbridge Professor Martina Micheletti and Dr Andrea Ducci Evaluating the impacts of pumping stress on aggregate formation during Tangential Flow Filtration Thomas Fanthom Professor Daniel Bracewell and Professor Paul Dalby Decisional tool to aid portfolio selection decisions into new modalities. Annabel Lyle Professor Suzanne Farid and Dr Stephen Goldrick Development of a scalable and consistent process for the production of lentivirus for gene-modified cell therapies Carme Ripoll Fiol Dr Qasim Rafiq and Dr Andrea Rayat Development and optimisation of novel bioprinting process for scalable production of tissue models using FRESH technique Patricia Santos Beato Dr Deepak Kalaskar and Dr Ryo Torri
- 2018/2019
Project title Researcher Supervisor(s)/Industrial Partner Development of a microfluidic bioanalytical device for the characterization of cellular therapeutic products Jorge Aranda-Hernandez Professor Nicolas Szita and Dr Alex Kiparissides Optimal Bioreactor: concept / design and implementation for CAR-T cell production
Alexander Davidson Dr Qasim Rafiq and Professor Dan Bracewell Ultra scale-down studies to investigate the impact of pre-column filtration on resin re-use and column fouling Ifham Mirza
Dr Andrea Rayat and Dr Martina Micheletti
Sterilisable, biocompatible, immersible, spectroscopic planar imaging system
Rob Platten Dr Qasim Rafiq and Professor Dan Bracewell Continuous manufacture of lentivirus vectors for therapeutic vaccine applications Dale Stibbs Dr Andrea Rayat and Dr Qasim Rafiq Optical deconvolution of multiple co-eluting proteins in chromatography Deniz Ucan Professor Paul Dalby and Dr Alex Kiparissides - 2017/2018
Project title Researcher Supervisor(s)/Industrial Partner A high throughput, multidimensional approach to engineering biology using automated workflows
Shama Chilakwad Profs Gary Lye and John Ward
Synthace
Process development for recovery and purification of exosomes for regenerative therapy
Benjamin Barnes Prof Dan Bracewell
ReNeuron
Development of an automated turbidostat platform for the investigation and characterization
of the effects of environmental and process parameters on the physiology and metabolism of green algae
Matthew Booth Drs Alex Kiparissides and Martina Micheletti
Algenuity
Continuous Bioprocess Facilities of the Future: Integrated Drug Development & Manufacturing Economics Evaluation Hanna Mahal Prof Suzy Farid and Dr Ajoy Velayudhan
CPI
Process interactions between filtration and chromatographic steps in mAb processing Maria Parau Profs Dan Bracewell and Mike Hoare
Fujifilm
An ultra scale-down study of normal flow depth filtration for bioprocess recovery Fathima Shazeena Rauf Profs Mike Hoare and Dan Bracewell
PALL
- 2016/2017
Project title Researcher Supervisors/Industrial Partner Bioprocessing of human T-cells to advance cellular immunotherapies Elena Costratio Drs Ivan Wall and Martina Micheletti
Sonics
3D polymer scaffolds for the activation of CAR-T cell growth Rebecca Gunn Dr Farlan Veraitch and Prof. Dan Bracewell
Spheritech
Design, synthesis and evaluation of agarose chromatography resins to meet the evolving needs of biologics manufacture Greta Jasulaityte Prof. Dan Bracewell and Dr Alex Kiparissides
Purolite
An upstream process for removing contaminating cell types from primary T-cell preparations Elsa Noaks Dr Ivan Wall and Prof. Dan Bracewell
Autolus
Rapid cell culture process development and optimisation using a new micro bioreactor system and advanced modelling approaches Vincent Wiegmann Drs Frank Baganz and Alex Kiparissides
Applikon
- 2015/2016
Project title Researcher Supervisor(s) Development of DNA nanopores for unitisation in different biochemical applications Patrick Arnott Dr Stefan Howorka and Prof. Gary Lye Decisional tool for production planning across clinical development of biopharmaceutical portfolios Max Baron Profs Suzy Farid and Nigel Titchener-Hooker Supply chain economics of clinical and commercial autologous ex vivo cell-gene therapy manufacture Ruxandra Comisel Prof Suzy Farid and Dr Tarit Mukhopadhyay A Microfluidic approach to test for CQAs of lentiviral vectors for gene therapy vaccinations Joe Harvey Prof Nicolas Szita and Dr Tarit Mukhopadhyay A combined multi-scale modelling and experimental investigation of the effects of Lactate metabolism on mammalian cell bioprocessing Max Lularevic Drs Alex Kiparissides and Cloe Kontoravdi (Imperial) Efforts to establish Cocal-G enveloped lentiviral producers and Car19 transgene for the purpose of future bioprocessing and comparison to VSV-G Envelopes Chris Perry Drs Tarit Mukhopadhyay and Yasu Takeuchi Integrating upstream and recovery scale-down mimics with predictive modelling for the evaluation of the process's window of operation Martina Sebastian Profs Suzy Farid and Nigel Titchener-Hooker Designer virus like particle (VLP) assembly in microbial expression system Sarah Slack Dr Tarit Mukhopadhyay and Prof. Dan Bracewell Ultra scale-down mimics for perfusion culture: experimental and modelling optimisation study for rapid biopharmaceutical process development Molly Tregidgo Dr Martina Micheletti and Prof. Suzy Farid Simulating the effect of large scale bioreactor heterogeneities on cell culture performance: a combined experimental and modelling approach Roman Zakrzewski Prof Gary Lye and Dr Alex Kiparissides - 2014/2015
Project title Researcher Supervisor(s) The use of continuous flow bioconversion reactors in novel biorefinery applications Roberto Chiocchio Profs. Gary Lye and Process development for recovery and purification of exosomes for regenerative therapy Ivano Colao Dr Ivan Wall and Prof Dan Bracewell Ultra scale-down (USD) methods for enhanced insight of membrane processing of engineered proteins Lara Fernandez Cerezo Profs Mike Hoare and Gary Lye Development of an automated high-throughput purification methodology for macromolecular medicines Vivien Fischer Profs Aly Velayudhan and Eric Fraga X-ray tomography for the characterisation of bioseparation materials Thomas Johnson Prof Dan Bracewell and Dr Paul shearing A scale-down engineering study of key steps in the manufacture of a medicinal toxin Darryl Kong Profs Nigel Titchener-Hooker and Dan Bracewell Nanoscale high-throughput whole-process analytics to monitor key quality attributes Zaenab Oshinbolu Profs Dan Bracewell and Paul Dalby - 2013/2014
Project title Researcher Supervisor(s) Gene Delivery Vector Platforms for Novel Gene Therapies Ali Sadfer Dr Darren Nesbeth, Prof Chris Mason Real-Time Visualisation of Protein Self-Assembly Hasan Alkaseem Dr Bart Hoogenboom, Dr Daniel Bracewell Novel Chassis for Engineered Pathways Aisha Asra Prof John Ward Ruchika Bandekar Prof Gary Lye Financial and Operational Perspectives of Cell Therapy Bioprocessing Tania Chilma Dr Suzanne Farid, Dr Sofia Simaria Optimisation of Antibody Expression and Recovery from High Cell Density Microbial Fermentations at the Microwell Scale Mary Lunson Prof Gary Lye Understand cell lysis in fermentation and primary recovery by online viscosity sensor Joseph Newton Dr Yuhong Zhou Bioabsorbable tracheal scaffolds for clinical application Toby Proctor Prof Chris Mason, Dr Farlan Veraitch S-Layer Lattice Assembly for Biotechnological Applications Bouran Sohrabi Dr Stefan Howorka, Prof Gary Lye Leveraging High-Throughput Purification Data using Advanced Visualisation and Predictive Tools Christos Stamatis Dr. Suzanne Farid, Prof Nigel Titchener-Hooker Nanofibre Adsorbents as a Purification Platform for Emerging Viral Vectores and Vaccines Jordan Turnbull Dr Daniel Bracewell - 2012/2013
Title Researcher Supervisor(s) An Integrated Scale-Down Platform for the Extraction and Recovery of Periplasmically Expressed Complex Molecules from E.Coli Asma Ahmad Dr Martina Micheletti, Prof Eli Keshavarz-Moore Scalable Production of Tissue Engineered Microunits for Bone Regeneration Using Bioactive Glass Microshperes and Dynamic Culture Conditions David De Silva Thompson Dr Ivan Wall, Dr Martina Micheletti Primary recovery of high-value products from high cell density harvests Anne Marie De Villiers Dr Tarit Mukhopadhyay, Prof Nigel Titchener-Hooker Rapid Fermentation Process Optimisation using State-of-the-Art Mini Bioreactors and Advanced Modelling Approaches Aaron Erbas Dr Frank Baganz, Prof Gary Lye Induced Pluripotent Stem Cell Processing for Drug Discovery Platforms and Cell therapy Products: Process Economics Michael Jenkins Dr Suzanne Farid, Dr Sofia Simaria Evaluation of Biological and Process Options for Alkaline Biooxidations Johannes Kolmar Dr Frank Baganz Development of Synthetic Shear Tracer Particles for Scale-Down Models of Continuous Centrifugation and Density Gradient Ultra-Centrifugation and a Mimic of Various Vaccine Candidates Beatrice Melinek Dr Tarit Mukhopadhyay, Dr Daniel Bracewell Understanding Protease Contaminants during Biopharmaceutical Manufacture from CHO Cell Culture Damiano Migani Dr Daniel Bracewell, Prof Mark Smales A Comparison between Aqueous Two-Phase Extraction and Chromatography for the Separation of Novel Biopharmaceuticals using High Throughput Process Development (HTPD) Methodologies Nehal Patel Dr Daniel Bracewell, Dr Eva Sorensen Rapid Materialisation of Synthetic Biology Products James Rutley Prof Gary Lye, Dr Martina Micheletti Purification of Recombinnat Vaccinia Viruses for Cancer Therapy and Cancer Vaccine using Monolthic Column Technology David Vincent Dr Yuhong Zhou, Dr Daniel Bracewell - 2011/2012
Title Researcher Supervisor(s) Novel Strategies for Early Downstream Processing of High-Density Mammalian Cell Culture Georgina Espuny Garcia Del Real Dr Daniel Bracewell, Prof Michael Hoare Scale-Down Characterisation and Modelling of Harvest Operations in Cell Culture Processes Joseph Allen Prof Nigel Titchener-Hooker, Dr Suzanne Farid Developing a Novel and Cost-Effective Method of Purification or Therapeutic Proteins using Affinity Tags Adam McInally Prof Michael Hoare, Dr Paul Dalby Engineering Characterisation of Cylindrical Shaken Bioreactors for Improved Cell Culture Process Development and Scale-Up Gregorio Rodriguez Dr Martina Micheletti, Dr Andrew Ducci (UCL Chemical Engineering) Cell and Protein Engineering Strategies to Maximise the Recovery and Dimerisation of a Biotherapeutic Antibody-Enzyme Fusion Protein Produced in E.Coli Desmond Schofield Dr Darren Nesbeth, Dr Kerry Chester (UCL Oncology) Applications of an Ultra-Rapid Next-Gen Thermocycler in PCR-based Bioprocess Monitoring Alex Templar Dr Darren Nesbeth, Prof Eli Keshavarz-Moore An Upstream Platform for the Production of High Grade Heterologous Proteins in Pichia Pastoris Ben Weil Dr Darren Nesbeth, Dr Daniel Bracewell - 2010/2011
Title Researcher Supervisor(s) Scale Down and Optimisation of a Novel Second Generation Bioethanol Process Neil Conroy Prof Gary Lye, Dr Paul Dalby Microscale Methods for the Rapid Analysis of Antibiotic Compound Libraries and Systematic Downstream Process Design Haroon Khan Prof Gary Lye, Dr Nicholas Szita An Ultra Scale-Down Tool for the Predicitve Design of a Filtration Procedure for Preparation of Human Cell Therapies Chris Longster Prof Michael Hoare, Dr Ivan Wall Engineering Characterisation of Single-Use Wave-Type Bioreactors for Improved Cell Culture Process Development and Scale-Up Douglas Marsh Prof Gary Lye, Dr Martina Micheletti Design and Evaluation of an Internally Radiating Photobioreactor for Generic Application in the Algal Production of Biofuels, Biorenewable Chemicals and Biopharmaceuticals Kane Miller Prof Gary Lye, Dr Martina Micheletti High Throughput Protein Precipitation for Monoclonal Antibody Purification Chris Morris Prof Nigel Titchener-Hooker, Dr Paul Dalby Streamlined Purification and Process Understanding of Polysaccharide Vaccine Components Aaron Noyes Dr Tarit Mukhopadhyay, Prof Nigel Titchener-Hooker Towards a More Efficient Platform for Inclusion Body Processing from Engineered E.Coli Aminat Omotosho Prof Eli Keshavarz-Moore, Dr Gareth Mannall Novel Primary Recovery Srategies for High Cell Density Mammalian Cell Daria Popova Prof Nigel Titchener-Hooker, Dr Suzanne Farid Non-Geometric Scale Up of Chromatographic Separations of Biopharmaceuticals Jayan Senaratne Prof Nigel Titchener-Hooker, Dr Daniel Bracewell Controlling Early Cell Human Embryonic Stem Cell Fate with Growth Factors and Oxygen Concentration Vishal Sharma Dr Farlan Veraitch, Dr Nicholas Szita Production Planning across Multi-Site, Multi-Product Biopharmaceutical Plants under Uncertainty Cyrus Siganporia Dr Suzanne Farid, Dr Lazaros Papageorgiou - 2009/2010
Title Researcher Supervisor(s) Improving Bone Marrow Stem Cell Therapy for Cardiac Repair Owen Bain Dr Ivan Wall, Prof Chris Mason Incorporation of Developability into Cell Line Selection: Creation of a Simplified High-Throughput Small-Scale Model for a mAb Manufacturing Process John Betts Prof Gary Lye, Dr Frank Baganz Small Scale, High Throughput Process Development with a Focus on Novel Therapeutic Proteins Alex Chatel Prof Mike Hoare, Prof Nigel Titchener-Hooker Process Modelling Approaches to Biological Complexity in the Production of Therapeutic Proteins Edward Close Dr Daniel Bracewell, Dr Eva Sorensen Microscale Characterisaton of a Manufacturing Route for Lentiviral Vectors Heather Guy Dr Tarit Mukhopadhyay, Prof Gary Lye Measurement of Protein Self-Association Behaviour as a Determinant of Aggregation in Bioprocessing Krisztina Kovacs-Schreiner Dr Daniel Bracewell, Prof Michael Hoare A Microscale Purification Platform for the Study of Fusion Protein Recovery Eduardo Lau Prof Michael Hoare, Dr Paul Dalby Dental Stem Cells for Tooth Regeneration and Repair Yvonne Pang Dr Ivan Wall, Prof Chris Mason Scale-Up of Tissue Engineering Trachea using Adult Stem Cells Leanne Partington Dr Ivan Wall, Prof Chris Mason The Bioprocessing of Human Embryonic Stem Cells to Treat Blindness Iwan Thomas Roberts Prof Chris Mason, Prof Peter Coffey Investigation of IgG Aggregate Formation in Biopharmaceutical Processes; A Study of the Location and Mechanism of Aggregation Roumteen Tavakoli-Keshe Dr Daniel Bracewell, Prof Nigel Titchener-Hooker Scaling Omnicyte (Adult Stem Cells) Therapy for Safe, Effective and Affordable Clinical Use. Characterisation of miRNAs for Stem Cell Expansion and Regenerative Medicine John Thwaites Dr Ivan Wall, Prof Chris Mason Pre-Formulation Screening: High Throughput Tools to Formulate dABs and Predict Stability Profiles Udofoyo Uye Dr Paul Dalby, Prof Michael Hoare