UCL Department of Biochemical Engineering


Bioprocess Facility Design

Focusing on how to take a process from a paper design to a fully-operational facility

This module focuses on how to take a process from a paper design to fully-operational facility, and will enable you to:

  • Design a plant layout considering the relevant regulatory requirements.
  • Understand the impact of facility design requirements on costs.
  • Determine a project schedule including phases, installation, commissioning and validation.
  • Accurately interpret engineering drawings used in design.
  • Prepare a safety and environmental review to define risks, hazards and safety strategy.
  • Understand the role of contractors, work with them more effectively and analyse their proposals.
  • Network with sector leaders and subject matter experts.

This MBI is recommended for:

This course is intended for engineers, chemists, biologists, biochemists and biotechnologists who are interested in facility design for bioprocesses. Each concept and topic covered will be explained for the beginner - an example case study is followed through the sequence of steps followed when performing facility design, the example selected is drawn from the previous “Bioprocess Design & Economic Evaluation” course.

Typically, delegates are: R&D scientists, engineers or managers who need to learn more about the typical steps which constitute the preliminary design process in conjunction with the “Bioprocess Design & Economic Evaluation” course.

Module Leader

Daniel G. Bracewell is Professor of Bioprocess Analysis at the UCL Department of Biochemical Engineering. He has made major contributions to the fundamental understanding of biopharmaceutical purification operations, generating over £5.5 million in research funds including new international research collaborations with India and the USA. He has authored more than 90 peer reviewed journal articles in the area to date and currently supervises 15 doctoral and postdoctoral projects, many of these studies are in collaboration with industry. One such project became the technology basis from which the spinout Puridify (acquired by GE Healthcare) developed.

Programme Outline

Day 1

  • The life-cycle of an engineering project
  • Case Study: project schedule
  • An industrial case study of installation and commissioning

Day 2

  • Introduction to plant layout and design
  • Opportunities that modularization might provide
  • Case Study: Plant design and layout
  • Biological safety and containment

Day 3

  • HAZOPs in Bioprocessing
  • Facility layout and safety tour
  • Validation master plan

Day 4

  • Design project presentations to a panel of senior industrialists and discussion forum