Cellular mechanisms of hearing
Jonathan Ashmore, FRS
|Bernard Katz Professor of Biophysics UCL Ear Institute, 332 Gray's Inn Road, London WC1X 8EE|
|Tel: +44 (0)20 7679 8937 / 020 7679 6080 Internal: 28937|
|Fax: +44 (0) 20 7679 8990|
I started out my research career as a theoretical physicist and then switched to the biophysics of vision. But I hated sitting in darkened rooms! When I was appointed a lecturer in Sussex, I met people who were interested in hearing research and those lucky people weren’t sitting in dark rooms: they were in quiet rooms instead! Luckily for me, I was there at the time when the ideas of cellular physiology were being introduced into hearing research and it was also possible to carry across principles about how the eye worked and apply them to the ear. It was some years later, when I moved to Bristol, that I was truly able to set up my own group of hearing researchers. I like the way in which trying to understand hearing brings you into contact with geneticists, physicists, nanotechnologists, audiological clinicians and surgeons and at the same time it’s all firmly rooted in mainstream physiology. UCL is a fantastic place to do that, especially in the Ear Institute where scientists of many different disciplines are actually working side by side: they even share the same benches in some cases! I’m still like my Rock Around the Clock hair cell video. I was the first person to capture a hair cell changing length in time to music on video and although most of the work I’ve done recently has nothing to do with that, it is still a really fun clip!
My lab is now situated at the UCL Ear Institute - please visit my main site.
This laboratory works on the cellular mechanisms of hearing. We are particularly interested in outer hair cells of the cochlea. These cells are responsible for selectively amplifying the sound entering the ear and act by producing forces in response to a sound stimulus acting upon them. We are investigating how the motor works by using electrophysiology, imaging and other biophysical techniques. We are working on trying to understand how potassium ions flow through the cochlea and to do this we use large scale computer models to investigate the way in which individual cells within the organ of Corti integrate into creating a functional cochlea. With Chris Richards we are using 2 photon confocal microscopy to study how the fast synapse of the inner hair cell works. The laboratory is a member of UCL-LSIC and also has links with CoMPLEX, the Centre for the application of Mathematics and Physics to the Life Sciences to Experimental Biology where we are working on a DTI Beacon Project, and with the IMCB, the Interdepartmental Laboratory of Molecular and Cell Biology.
Rock Around The Clock Hair Cell Video. Download it as a 5Mb MPEG movie with sound or obtain an explanation of this movie! There are growing numbers of sites devoted to hearing research. These contain a wide variety of images, data and models. Some of these are sites that provide graphics and further explanation of the topics covered in an article appearing TINS APRIL 1998 : Nobili, Mammano and Ashmore: How well do we understand the cochlea? For web sites you might like to start at the Association for Research in Otolaryngology (ARO) where the virtual library is kept up to date with many ear related web sites The sites you will find your way to include:
- VIMM (a site from Padova illustrating the motion of travelling waves and organ of Corti)
- Promenade round the COCHLEA - a multilingual educational site from Montpellier
- Kuni Iwasa's web site, providing information on several aspects of outer hair cell function
- House Ear Clinic in Los Angeles, example of a commercial site with information of a clinical nature
- John's Hopkins Medical School site with a bias towards biomedical engineering
- Hearing and Balance at University of Wisconsin at Madison
- Digital warehouse of auditory models and data at Boston University
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