Synaptic mechanisms and signal processing

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Prof. Angus Silver
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Professor of Neuroscience and Wellcome Trust Senior Research Fellow
Tel: +44 (0)20 7679 7830
Email: a.silver@ucl.ac.uk
Members: Listing

The brain gathers information about the body and the surrounding world, allowing it to build internal representations and to plan and execute movement. Our lab works on how synapses, neurons and networks transmit and process such information and perform computations. The brain areas we investigate include the cerebellum and the sensory cortex. The main aim of our work is to develop a mechanistic understanding of brain function that links the molecular, synaptic, neuronal and network levels (Neuroscience). This requires a multidisciplinary approach that combines the most powerful experimental and theoretical methods available. To achieve this we both develop and apply new optical methods for measuring rapid signalling in 3D (Microscopy) and new software tools for data acquisition, analysis and modelling (Neuroinformatics). Application of these new experimental and theoretical approaches allows us to link neuronal mechanisms to information processing, thereby bridging different levels of description of brain function.

Publications

2010 2009 2008 2007 2006 2005 2004 2003 2002 2000 1999 1998 1997-1989 2010


Hallermann S, Fejtova A, Schmidt H, Weyhersmüller A, Silver RA, Gundelfinger ED, Eilers J (2010). Bassoon speeds vesicle reloading at a central excitatory synapse. Neuron. 2010 November 18; 68(4-6): 710–723. [PubMed]

Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D (2010). Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. J Comput Neurosci. 2010 Nov 4. [PubMed]

Vervaeke K, Lorincz A, Gleeson P, Farinella M, Nusser Z, Silver RA (2010). Rapid desynchronization of an electrically coupled interneuron network with sparse excitatory synaptic input. Neuron. 2010 Aug 12;67(3):435-51. [PubMed]

Gleeson P, Crook S, Cannon RC, Hines ML, Billings GO, Farinella M, Morse TM, Davison AP, Ray S, Bhalla US, Barnes SR, Dimitrova YD, Silver RA (2010). NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS Comput Biol 6(6) [PubMed] [DOI Link]

Kirkby PA, Nadella KMNS, Silver RA (2010). A compact acousto-optic lens for 2D and 3D femtosecond based 2-photon microscopy. Optics Express 18(13), 13720-13744 [PubMed] [DOI Link]

Silver RA (2010). Neuronal arithmetic. Nat Rev Neurosci 11(7), 474-489 [PubMed] [DOI Link]

2009



Crook S, Silver RA, Gleeson P (2009). Describing and exchanging models of neurons and neuronal networks with NeuroML. BMC NEUROSCIENCE. ( Vol. 10 ). BIOMED CENTRAL LTD. [DOI Link]

Rothman JS, Cathala L, Steuber V, Silver RA (2009). Synaptic depression enables neuronal gain control. Nature 457(7232), 1015-1018 [PubMed] [DOI Link]

2008



Arenz A, Silver RA, Schaefer AT, Margrie TW (2008). The contribution of single synapses to sensory representation in vivo. Science 321(5891), 977-980 [PubMed] [DOI link]

Gleeson P, Steuber V, Silver RA (2008). Using neuroConstruct to develop and modify biologically detailed 3D neuronal network models in health and disease. In Soltesz, I., Staley, K. (Eds.). Computational Neuroscience in Epilepsy. Elsevier.

Kanichay RT, Silver RA (2008). Synaptic and cellular properties of the feedforward inhibitory circuit within the input layer of the cerebellar cortex. Journal of Neuroscience 28(36), 8955-8967 [PubMed]

Kirkby PA, Silver RA, Nadella KMNS (2008). Imaging Apparatus and Methods  [Online]

Silver RA, Kanichay RT (2008). Neuroscience: Refreshing connections. Science 320(5873), 183-184 [PubMed] [DOI link]

2007



Crook S, Gleeson P, Howell F, Svitak J, Silver RA (2007). MorphML: Level 1 of the NeuroML Standards for Neuronal Morphology Data and Model Specification. Neuroinformatics 5(2), 96-104 [PubMed]

Digregorio DA, Rothman JS, Nielsen TA, Silver RA (2007). Desensitization properties of AMPA receptors at the cerebellar mossy fiber granule cell synapse. Journal of Neuroscience 27(31), 8344-8357 [PubMed] [DOI link]

Gleeson P, Steuber V, Silver RA (2007). neuroConstruct: a tool for modeling networks of neurons in 3D space. Neuron 54(2), 219-235 [PubMed] [DOI link]

Saviane C, Silver RA (2007). Estimation of quantal parameters with multiple-probaility fluctuation analysis. In Patch-Clamp Methods and Protocols (403 ed. pp.303-317). Humana Press.

Silver RA, Farrant M (2007). Neurotransmitter-gated channels in dendrites. In Stuart, G., Spruston, N., Häusser, M. (Eds.). Dendrites (2nd ed. pp.190-223). Oxford: Oxford University Press.

Steuber V, Mittmann W, Hoebeek FE, Silver RA, De Zeeuw CI, Hausser M, De Schutter E (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron 54(1), 121-136 [PubMed] [DOI link]

2006



Saviane C, Silver RA (2006). Errors in the estimation of the variance: Implications for multiple-probability fluctuation analysis. Journal of Neuroscience Methods 153(2), 250-260 [PubMed] [DOI link]

Saviane C, Silver RA (2006). Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse. Nature 439(7079), 983-987 [PubMed] [DOI link]

2005



Sargent PB, Saviane C, Nielsen TA, Digregorio DA, Silver RA (2005). Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse. Journal of Neuroscience 25(36), 8173-8187 [PubMed]

Thompson SM, Kao JP, Kramer RH, Poskanzer KE, Silver RA, Digregorio DA, Wang SS (2005). Flashy science: controlling neural function with light. Journal of Neuroscience 25(45), 10358-10365 [PubMed]

2004



Nielsen TA, Digregorio DA, Silver RA (2004). Modulation of glutamate mobility reveals the mechanism underlying slow-rising AMPAR EPSCs and the diffusion coefficient in the synaptic cleft. Neuron 42(5), 757-771 [PubMed] [DOI link]

Semyanov A, Walker MC, Kullmann DM, Silver RA (2004). Tonically active GABA(A) receptors: modulating gain and maintaining the tone. Trends in Neurosciences 27(5), 262-269 [PubMed]

2003 2002



Mitchell SJ, Silver RA (2003). Shunting inhibition and mGluR-mediated disinhibition modulate the gain of granule cell input-output relationships during synaptic excitation in rat cerebellum. Journal of Physiology. ( Vol. 547P pp.C88-).

Mitchell SJ, Silver RA (2003). Shunting inhibition modulates neuronal gain during synaptic excitation. Neuron 38(3), 433-445 [PubMed] [DOI link]

Momiyama A, Silver RA, Hausser M, Notomi T, Wu Y, Shigemoto R, Cull-candy SG (2003). The density of AMPA receptors activated by a transmitter quantum at the climbing fibre-Purkinje cell synapse in immature rats. The Journal of Physiology 549, 75-92 [PubMed]

Nielsen TA, Digregorio DA, Silver RA (2003). Release probability-dependent changes of the AMPA receptor EPSC waveform at the rat cerebellar mossy fibre to granule cell synapse. Journal of Physiology. ( Vol. 547P pp.C33-).

Silver RA (2003). Estimation of nonuniform quantal parameters with multiple-probability fluctuation analysis: theory, application and limitations. Journal of Neuroscience Methods 130(2), 127-141 [PubMed]

Silver RA, Lubke J, Sakmann B, Feldmeyer D (2003). High-probability uniquantal transmission at excitatory synapses in barrel cortex. Science 302, 1981-1984 [PubMed] [DOI link]




Digregorio DA, Nusser Z, Silver RA (2002). Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapse. Neuron 35(3), 521-533 [PubMed] [DOI link]

Feldmeyer D, Lubke J, Silver RA, Sakmann B (2002). Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column. The Journal of Physiology 538(3), 803-822 [Pubmed]

Sargent PB, Silver RA (2002). Stationary and non-stationary quantal analysis of glutamate release at mossy fibre-granule cell synapses in the rat cerebellum. [Abstract]

2000



Clements JD, Silver RA (2000). Unveiling synaptic plasticity: a new graphical and analytical approach. Trends in Neurosciences 23(3), 105-113 [PubMed]

Feldmeyer D, Lubke J, Silver RA, Sakmann B (2000). Physiology of synaptic connections between spiny layer 4 neurones and layer 2/3 pyramidal cells in rat barrel cortex. Society for Neuroscience Abstracts. ( Vol. 26 pp.2105P-).

Feldmeyer D, Silver RA, Lubke J, Sakmann B (2000). Physiology of synaptic connections between spiny layer 4 neurones and layer 2/3 pyramidal cells in rat barrel cortex. EUR J NEUROSCI 12, 365-365.

Lubke J, Feldmeyer D, Silver RA, Sakmann B (2000). Morphology of synaptic connections between spiny layer 4 neurones and layer 2/3 pyramidal cells in rat barrel cortex. EUR J NEUROSCI 12, 14-14

Mitchell SJ, Silver RA (2000). GABA spillover from single inhibitory axons suppresses low-frequency excitatory transmission at the cerebellar glomerulus. Journal of Neuroscience 20(23), 8651-8658 [PubMed]

Mitchell SJ, Silver RA (2000). GABA spillover selectively inhibits low frequency excitatory transmission at cerebellar mossy fibres. Society for Neuroscience Abstracts. ( Vol. 26 pp.882P-).

Mitchell SJ, Silver RA (2000). Glutamate spillover suppresses inhibition by activating presynaptic mGluRs. Nature 404(6777), 498-502 [PubMed]

1999



Feldmeyer D, Silver RA, Lubke J, Sakmann B (1999). Synaptic connections between spiny layer 4 neurones and layer 2/3 pyramidal cells of rat barrel cortex. Journal of Physiology. ( Vol. 518 pp.141-).

Mitchell SJ, Silver RA (1999). Heteroreceptor mediated presynaptic inhibition at the glomerulus of the rat cerebellum. Society for Neuroscience Abstracts. ( Vol. 25 ).

Mitchell SJ, Silver RA (1999). Reciprocal presynaptic inhibition at the cerebellar glomerulus of the rat. Journal of Physiology. ( Vol. 518 pp.143-).

Silver RA, Farrant M (1999). Neurotransmitter-gated channels in dendrites. In Stuart, G., Spruston, N., Häusser, M. (Eds.). Dendrites ( pp.114-138). Oxford University Press.

1999



Silver RA (1998). Neurotransmission at synapses with single and multiple release sites. In Faber, D. S., Korn, H., Redman, S. J., Thomson, S. M., Altman, J. (Eds.). Central Synapses: quantal mechanisms and plasticity ( pp.130-139). Strasbourg:

Silver RA, Momiyama A, Cull-candy SG (1998). Locus of frequency-dependent depression identified with multiple-probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses. The Journal of Physiology 510, 881-902 [PubMed]

1997 - 1989



Silver RA, Momiyama A, Cull-candy SG (1997). Transmitter release and quantal size at cerebellar climbing fibre-Purkinje cell synapses of the rat. Journal of Physiology. ( Vol. 501P pp.14P-).

Silver RA, Colquhoun D, Cull-candy SG, Edmonds B (1996). Deactivation and desensitization of non-NMDA receptors in patches and the time course of EPSCs in rat cerebellar granule cells. The Journal of Physiology 493(1), 167-173 [PubMed]

Silver RA, Cull-candy SG, Takahashi T (1996). Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites. The Journal of Physiology 494(1), 231-250 [PubMed]

Silver RA, Colquhoun D, Cullcandy SG, Edmonds B (1994). MECHANISMS UNDERLYING DECAY OF THE FAST COMPONENT OF EPSCS IN RAT CEREBELLAR GRANULE CELLS. J PHYSIOL-LONDON 476P, P67-P68.

Sarantis M, Ballerini L, Miller B, Silver RA, Edwards M, Attwell D (1993). Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current. Neuron 11(3), 541-549.

Silver RA, Traynelis SF, Cull-candy SG (1992). Rapid-time-course miniature and evoked excitatory currents at cerebellar synapses in situ. Nature 355(6356), 163-166.

Silver RA, Whitaker M, Bolsover SR (1992). Intracellular ion imaging using fluorescent dyes: artefacts and limits to resolution. Pflugers Arch 420(5-6), 595-602.

Bolsover S, Silver RA (1991). Artifacts in calcium measurement: recognition and remedies. Trends Cell Biol 1(2-3), 71-74.

Silver RA, Bolsover SR (1991). Expression of T-type calcium current precedes neurite extension in neuroblastoma cells. J Physiol (Paris) 85(2), 79-83.

Silver RA, Lamb AG, Bolsover SR (1990). Calcium hotspots caused by L-channel clustering promote morphological changes in neuronal growth cones. Nature 343(6260), 751-754 [DOI Link]

Silver RA, Lamb AG, Bolsover SR (1989). Elevated cytosolic calcium in the growth cone inhibits neurite elongation in neuroblastoma cells: correlation of behavioral states with cytosolic calcium concentration. J Neurosci 9(11), 4007-4020.