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Christopher Yeo

Department of Neuroscience, Physiology & Pharmacology

Learning, memory and the cerebellum

The cerebellum has been likened to a neuronal machine making critical contributions to sensory-motor control, motor learning and cognition. Its cortical neurons are in a regularly repeating, geometrical array that suggests an information-processing algorithm consistent across every region. Classical conditioning of the eyeblink response is an excellent model of associative learning and recent work has defined cerebellar circuitry essential for its learning and expression. These advances provide an outstanding opportunity to analyse an identified neural network operating under natural conditions to develop a specified and accurately measurable learned behaviour. We are working to characterise the cerebellar algorithm using molecular, behavioural/pharmacological, multiple single-unit electrophysiology and computational methods.


1) Behavioural/pharmacological analysis of cerebellar function in acquisition and consolidation of motor memories

2) In vivo, electrophysiological analysis of motor learning


Cooke S, Attwell PJE, Yeo CH (2004)
Temporal properties of cerebellar-dependent memory consolidation.
J Neurosci 24:2934 –2941

Attwell PJE, Cooke S, Yeo CH (2002)
Cerebellar function in consolidation of a motor memory.
Neuron 34:1011-1020

Attwell PJE, Rahman S, Yeo CH (2001)
Acquisition of eyeblink conditioning is critically dependent upon normal function in cerebellar cortical lobule HVI.
J Neurosci 21:5715-5722


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