Developmental Neurosciences headshot

Head of Programme

Professor Francesco Muntoni

Helen Cross

Deputy Head

Professor Helen Cross


Developmental Neurosciences
UCL Great Ormond Street Institute of Child Health
30 Guilford Street
London WC1N 1EH

Programme Enquiries: email

Selected Publications

Developmental Neurosciences logo

Mutations in the histone methyltransferase gene KMTB2 cause complex early-onset dystonia Esther Meyer, Keren J Carss, Julia Rankin, John M E Nichols, Detelina Grozeva, Agnel P Joseph,    Niccolo E Mencacci, Apostolos Papandreou,    Joanne Ng, Serena Barral, Adeline Ngoh, Hilla Ben-Pazi, Michel A Willemsen, David Arkadir,    Angela Barnicoat, Hagai Bergman, Sanjay Bhate,    Amber Boys, Niklas Darin, Nicola Foulds,    Nicholas Gutowski, Alison Hills, Henry Houlden,    Jane A Hurst, Zvi Israel et al

Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial Finbar J K O'Callaghan, Stuart W Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L Johnson, Colin R Kennedy, Marcus Likeman, Andrew L Lux, Mark Mackay, Andrew A Mallick, Richard W Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M Verity, John P Osborne

Interictal epileptiform discharges have an independent association with cognitive impairment in children with lesional epilepsy Jennifer M.Glennon, Louise Weiss-Croft, Sue Harrison, J.Helen Cross, Stewart G.Boyd, Torsten Baldeweg

Altered levels of MicroRNA-9, -206 and -132 in Spinal Muscular Atrophy and Their Response to Antisense Oligonucleotide Therapy Francesco Catapano, Irina Zaharieva, Mariacristina Scoto, Elena Marrosu, Jennifer Morgan, Francesco Muntoni and Haiyan Zhou

Developmental Neurosciences Programme

The primary focus of the Developmental Neuroscience Programme is to minimise the impact of disorders affecting the developing central and peripheral nervous system by: 

  • Studying the mechanisms of injury and repair
  • Improving diagnosis and prognosis
  • Evaluating therapeutic strategies
  • Optimising functional outcome

Using a life-span approach, we link laboratory-based neuroscience techniques with clinical research to investigate neurodevelopmental and acquired disorders affecting the young brain and peripheral nervous system. Our goal is to translate novel research findings into clinical practice. We use innovative technologies to relate genetic and anatomical markers of disease to normal and abnormal indices of cognitive, motor, behavioural, and mental health processes. By promoting early diagnosis, we aim to improve the management and treatment of affected children not only within GOSH and UCL Health Partners, but also nationally and internationally. Finally we undertake both early experimental and larger confirmatory clinical trials to contribute to the development of national guidelines and policies, and set national/international standards of clinical care for children with neurodevelopmental disorders and/or rare diseases affecting central and peripheral nervous system function.

Developmental Neurosciences brochure (pdf)


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