UCL Great Ormond Street Institute of Child Health


Great Ormond Street Institute of Child Health


Dubowitz Neuromuscular Centre

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The Dubowitz Neuromuscular Centre (DNC) provides a multidisciplinary service as a leading clinical and research centre specialising in neuromuscular disorders affecting individuals in the paediatric age.  The DNC provides clinical assessment, diagnostic services, advice on treatment and rehabilitation, and is involved in clinical trials and in basic  research focused on understanding the cause of neuromuscular diseases in childhood, and identifying novel therapeutic intervention.  Excellence in this field is demonstrated not only by the National Commissioning Group (NCG) status achieved in 2000 to provide a national specialist diagnostic and assessment service for Congenital Muscular Dystrophies and Congenital Myopathies, but also by the designation as a muscle centre by the Muscular Dystrophy Campaign. 

The DNC is  also part of the Great Ormond Street NHS Trust and is a member of the MRC Neuromuscular Translational Research Centre at UCL. In addition to the service provided for all paediatric neuromuscular disorders, the DNC is involved with clinical, molecular and cell biological research mostly focused on the genetic basis of congenital muscular dystrophies, on muscle stem cell, cell fusion and on experimental therapies for Duchenne muscular dystrophy.

The Muscle biopsy service is located close by at the Institute of Neurology at Queen Square. A dedicated team with expertise in paediatric muscle conditions works closely with adult muscle and nerve pathology service

COVID-19 information from the Great Ormond Street Neuromuscular Team

Many families are contacting us to request information on how they should interpret the recent governmental guideline on vulnerable populations, especially when it comes to attendance to school.

The GOSH neuromuscular clinical team consensus is that the following patients should follow social distancing, including no school/college/social gatherings. ( https://www.gov.uk/government/publications/covid-19-guidance-on-social-distancing-and-for-vulnerable-people/guidance-on-social-distancing-for-everyone-in-the-uk-and-protecting-older-people-and-vulnerable-adults)

1) children on oral steroids (example DMD) and Myasthenia gravis

2) Children at respiratory  risk (ventilated, respiratory function (FVC) <60%, Congenital myasthenic syndromes, advised influenza vaccine)

Many families have asked what they should also do with their additional healthy siblings.

At the moment this is a parental choice, until further DOH guidance


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