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Understanding the biology of longevity and ageing using a nematode model
A focus of current work in this laboratory is understanding the biological mechanisms that cause pathologies of ageing, and how such pathologies lead to mortality; and how reduced insulin/IGF-1 signalling and dietary restriction suppress ageing and increase lifespan. Other interests include the mechanisms of organismal death, sex differences in the biology of ageing, the role of the microbiome in ageing, evolutionary conservation of mechanisms of ageing, and bioethical implications of ageing research. Funded for our research has been received from the BBSRC, the European Union and the Wellcome Trust.
Research Team
Reva Biju, M.Sc. student, email: reva.biju.22@ucl.ac.uk
Autumn 2022: New article in GeroScience arguing that the term "cellular senescence" is outdated and needs replacing. New article in Ageing Research Reviews describing the hyperfunction and programmatic theories of ageing. New article in Frontiers in Cell and Developmental Biology arguing that C. elegans experience semelparous reproductive death. For details see publications.
Hear Bruce Zhang talk about the new helminth infection and inflammageing theory in a Naked Scientists podcast
Updated on
21st February 2023
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![]() SPIM image of a pharynx in a wild-type (N2) C. elegans on day 8 of adulthood (20˚C) where the terminal bulb is infected with RFP labelled E. coli. This will eventually lead to P death, the cause of death of ~40% of senescent wild-type C. elegans (Zhao et al. Nature Communications, 2017). Movie generated by H. Wang. Links Gems Lab Publications | About David Gems | Postgraduate opportunities in Gems lab | IHA main page | Genetics, Evolution and Environment | UCL home page C. elegans Links What is C. elegans | Wormbase | C. elegans Genetics Center | Nematode Net More links NCBI | CEE | Who's Who in Gerontology | Enhancement Technologies | UCL Library | PubMed | Google
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