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Understanding the biology of longevity and ageing using a nematode model
A focus of current work in this laboratory is understanding the biological mechanisms that cause pathologies of ageing, and how such pathologies lead to mortality; and how reduced insulin/IGF-1 signalling and dietary restriction suppress ageing and increase lifespan. Other interests include the mechanisms of organismal death, sex differences in the biology of ageing, the role of the microbiome in ageing, evolutionary conservation of mechanisms of ageing, and bioethical implications of ageing research. Our work is largely funded by the European Union and the Wellcome Trust.
Research Team
Evgeniy Galimov, Postdoc, email: e.galimov@ucl.ac.uk
2018: Four new studies, in Cell Reports (rated exceptional by F1000), NPJ Aging and Mechanisms of Disease, Aging, and Current Biology. For details see: publication list
Short film about Gems lab work
Updated on
7th January 2019
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![]() SPIM image of a pharynx in a wild-type (N2) C. elegans on day 8 of adulthood (20˚C) where the terminal bulb is infected with RFP labelled E. coli. This will eventually lead to P death, the cause of death of ~40% of senescent wild-type C. elegans (Zhao et al. Nature Communications, 2017). Movie generated by H. Wang. Links Gems Lab Publications | About David Gems | Ph.D. opportunities in Gems lab | IHA main page | Genetics, Evolution and Environment | UCL home page C. elegans Links What is C. elegans | Wormbase | C. elegans Genetics Center | bionet.celegans newsgroup | Info from C. elegans labs | Nematode Net More links NCBI | CEE | Who's Who in Gerontology | Enhancement Technologies | UCL Library | PubMed | Google
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