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UK Dementia Research Institute at UCL

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Prof John Hardy

Prof John Hardy

Chair of the Molecular Biology of Neurological Disease

Neurodegenerative Diseases

UCL Queen Square Institute of Neurology

Joined UCL
1st Apr 2007

Research summary

My research interests are in the genetic analysis of disease. Historically, we have worked on the genetic analysis of Alzheimer's disease and other dementias. More recently, we have worked on Parkinson's disease and other movement disorders and, most recently on motor neuron disease. Our early studies were on mendelian forms of disease and these studies continue, but an increasing focus has been on the genetic analysis of complex traits related to disease. Additionally, this latter analysis has made us increasingly interested in population genetics because the risk variants for human traits are likely to be different in different racial groups.

In all cases our intention is to develop an understanding of the underlying genetics of a disorder so we can work with those making cellular and animal models of the disease to help, both in the unerstanding of disease mechanisms and to help in the search for treatements. In this regard, we therefore have three types of collaborations: collaborations with clinicians who treat patients with disease, especially colleagues at the Institute of Neurology, but also elsewhere, collaborations with other geneticists to collaboratively analyse such patient material, and collaborations with cell biologists and transgenic mice people to eneble them to build good models of disease.

Education

Imperial College of Science, Technology and Medicine
PhD, Biochemistry | 1981
University of Leeds
BSc, Biochemistry | 1976

Biography

John Hardy is the Chair of Molecular Biology of Neurological Disease at the UCL Institute of Neurology with over 23,000 citations. In recognition of his exceptional contributions to science, he was elected a Fellow of the Royal Society in 2009.

Publications