2024 Publications

The 2023 UN high-level meeting on tuberculosis: Renewing hope, momentum, and commitment to end tuberculosis. (2024) Millington, K. A., White, R. G., Lipman, M., McQuaid, C. F., Hauser, J., Wooding, V., Potter, J., Abubakar, I., and Wingfield, T. Lancet Respir Med 12, 10-13: https://doi.org/10.1016/S2213-2600(23)00409-5.

BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery. (2024) Bonjorno, A. F., Pavan, A. R., Fernandes, G. F. S., Scarim, C. B., Castagnolo, D., and Dos Santos, J. L. Front Chem 12, 1358539: https://doi.org/10.3389/fchem.2024.1358539.

Bioarchaeological investigation of individuals with suspected multibacillary leprosy from the mediaeval leprosarium of St Mary Magdalen, Winchester, Hampshire, UK. (2024) Taylor, G. M., White-Iribhogbe, K., Cole, G., Ashby, D., Stewart, G. R., and Dawson-Hobbis, H. J Med Microbiol 73 https://doi.org/10.1099/jmm.0.001806.

Blazing the trail for innovative tuberculosis diagnostics. (2024) Yerlikaya, S., Broger, T., Isaacs, C., Bell, D., Holtgrewe, L., Gupta-Wright, A., Nahid, P., Cattamanchi, A., and Denkinger, C. M. Infection 52, 29-42: https://doi.org/10.1007/s15010-023-02135-3.

Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis. (2024) Nimmo, C., Ortiz, A. T., Tan, C. C. S., Pang, J., Acman, M., Millard, J., Padayatchi, N., Grant, A. D., O'Donnell, M., Pym, A., Brynildsrud, O. B., Eldholm, V., Grandjean, L., Didelot, X., Balloux, F., and van Dorp, L. Genome Med 16, 34: https://doi.org/10.1186/s13073-024-01289-5.

Diagnosis and management of tuberculosis infection in inclusion health populations in London. (2024) Gray, A., Surey, J., Veitch, M., Menezes, D., Gibbons, J., Leonard, M., Sultan, B., Esmail, H., and Story, A. BMC Infect Dis 24, 252: https://doi.org/10.1186/s12879-024-09132-3.

Diagnostic accuracy of a three-gene Mycobacterium tuberculosis host response cartridge using fingerstick blood for childhood tuberculosis: A multicentre prospective study in low-income and middle-income countries. (2024) Olbrich, L., Verghese, V. P., Franckling-Smith, Z., Sabi, I., Ntinginya, N. E., Mfinanga, A., Banze, D., Viegas, S., Khosa, C., Semphere, R., Nliwasa, M., McHugh, T. D., Larsson, L., Razid, A., Song, R., Corbett, E. L., Nabeta, P., Trollip, A., Graham, S. M., Hoelscher, M., Geldmacher, C., Zar, H. J., Michael, J. S., Heinrich, N., and RaPaed, T. B. c. Lancet Infect Dis 24, 140-149: https://doi.org/10.1016/S1473-3099(23)00491-7.

Evaluation of the Xpert MTB Host Response assay for the triage of patients with presumed pulmonary tuberculosis: A prospective diagnostic accuracy study in Viet Nam, India, the Philippines, Uganda, and South Africa. (2024) Gupta-Wright, A., Ha, H., Abdulgadar, S., Crowder, R., Emmanuel, J., Mukwatamundu, J., Marcelo, D., Phillips, P. P. J., Christopher, D. J., Nhung, N. V., Theron, G., Yu, C., Nahid, P., Cattamanchi, A., Worodria, W., Denkinger, C. M., and Network, R. D. T. Lancet Glob Health 12, e226-e234: https://doi.org/10.1016/S2214-109X(23)00541-7.

A flexible multi-metric Bayesian framework for decision-making in Phase II multi-arm multi-stage studies. (2024) Dufault, S. M., Crook, A. M., Rolfe, K., and Phillips, P. P. J. Stat Med 43, 501-513: https://doi.org/10.1002/sim.9961.

Healthcare provisions associated with multiple HIV-related outcomes among adolescent girls and young women living with HIV in South Africa: a cross-sectional study. (2024) Toska, E., Zhou, S., Laurenzi, C. A., Saal, W., Rudgard, W., Wittesaele, C., Langwenya, N., Jochim, J., Banougnin, B. H., Gulaid, L., Armstrong, A., Sherman, G., Edun, O., Sherr, L., and Cluver, L. J Int AIDS Soc 27, e26212: https://doi.org/10.1002/jia2.26212.

HIV, multimorbidity, and health-related quality of life in rural KwaZulu-Natal, South Africa: A population-based study. (2024) Stanton, A. M., Boyd, R. L., O'Cleirigh, C., Olivier, S., Dolotina, B., Gunda, R., Koole, O., Gareta, D., Modise, T. H., Reynolds, Z., Khoza, T., Herbst, K., Ndung'u, T., Hanekom, W. A., Wong, E. B., Pillay, D., Siedner, M. J., and Vukuzazi Study, T. PLoS One 19, e0293963: https://doi.org/10.1371/journal.pone.0293963.

Integrating molecular microbial methods to improve faecal pollution management in rivers with designated bathing waters. (2024) Karunakaran, E., Battarbee, R., Tait, S., Brentan, B. M., Berney, C., Grinham, J., Herrero, M. A., Omolo, R., and Douterelo, I. Sci Total Environ 912, 168565: https://doi.org/10.1016/j.scitotenv.2023.168565.

Isoniazid preventive therapy completion between July-September 2019: A comparison across HIV differentiated service delivery models in Uganda. (2024) Mugenyi, L., Namuwenge, P. M., Ouma, S., Bakashaba, B., Nanfuka, M., Zech, J., Agaba, C., Mijumbi Ojok, A., Kaliba, F., Bossa Kato, J., Opito, R., Miya, Y., Katureebe, C., and Hirsch-Moverman, Y. PLoS One 19, e0296239: https://doi.org/10.1371/journal.pone.0296239.

Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture. (2024) Schurz, H., Naranbhai, V., Yates, T. A., Gilchrist, J. J., Parks, T., Dodd, P. J., Moller, M., Hoal, E. G., Morris, A. P., Hill, A. V. S., and International Tuberculosis Host Genetics, C. Elife 13 https://doi.org/10.7554/eLife.84394.

Mycobacterial FtsEX-RipC interaction is required for normal growth and cell morphology in rifampicin and low ionic strength conditions. (2024) Samuels, V., Mulelu, A. E., Ndlovu, H., and Marakalala, M. J. Microbiol Spectr, e0251523: https://doi.org/10.1128/spectrum.02515-23.

Non-tuberculous mycobacterial pulmonary disease (NTM-PD): Epidemiology, diagnosis and multidisciplinary management. (2024) Kumar, K., Ponnuswamy, A., Capstick, T. G., Chen, C., McCabe, D., Hurst, R., Morrison, L., Moore, F., Gallardo, M., Keane, J., Harwood, S., Sinnett, T., Bryant, S., Breen, R., Kon, O. M., Lipman, M., Loebinger, M. R., and Dhasmana, D. J. Clin Med (Lond) 24, 100017: https://doi.org/10.1016/j.clinme.2024.100017.

Phenotype versus genotype discordant rifampicin susceptibility testing in tuberculosis: Implications for a diagnostic accuracy. (2024) Qadir, M., Faryal, R., Khan, M. T., Khan, S. A., Zhang, S., Li, W., Wei, D. Q., Tahseen, S., and McHugh, T. D. Microbiol Spectr 12, e0163123: https://doi.org/10.1128/spectrum.01631-23.

Quantifying non-adherence to anti-tuberculosis treatment due to early discontinuation: a systematic literature review of timings to loss to follow-up. (2024) Walker, E. F., Flook, M., Rodger, A. J., Fielding, K. L., and Stagg, H. R. BMJ Open Respir Res 11https://doi.org/10.1136/bmjresp-2023-001894.

Radiographic characteristics of rifampicin-resistant tuberculosis in the STREAM stage 1 trial and their influence on time to culture conversion in the short regimen. (2024) Chiang, C. Y., Bern, H., Goodall, R., Chien, S. T., Rusen, I. D., Nunn, A., and Collaborators, S. S.-s. BMC Infect Dis 24, 144: https://doi.org/10.1186/s12879-024-09039-z.

Screening for tuberculosis infection and effectiveness of preventive treatment among people with HIV in low-incidence settings. (2024) van Geuns, D., Arts, R. J. W., de Vries, G., Wit, F., Degtyareva, S. Y., Brown, J., Pareek, M., Lipman, M., and van Crevel, R. AIDS 38, 193-205: https://doi.org/10.1097/QAD.0000000000003747.

Short oral regimens for pulmonary rifampicin-resistant tuberculosis (TB-PRACTECAL): an open-label, randomised, controlled, phase 2B-3, multi-arm, multicentre, non-inferiority trial. (2024) Nyang'wa, B. T., Berry, C., Kazounis, E., Motta, I., Parpieva, N., Tigay, Z., Moodliar, R., Dodd, M., Solodovnikova, V., Liverko, I., Rajaram, S., Rassool, M., McHugh, T., Spigelman, M., Moore, D. A., Ritmeijer, K., du Cros, P., Fielding, K., and team, T.-P. Lancet Respir Med 12, 117-128: https://doi.org/10.1016/S2213-2600(23)00389-2.

Tuberculosis treatment monitoring tests during routine practice: study design guidance. (2024) MacLean, E. L., Zimmer, A. J., den Boon, S., Gupta-Wright, A., Cirillo, D. M., Cobelens, F., Gillespie, S. H., Nahid, P., Phillips, P. P., Ruhwald, M., and Denkinger, C. M. Clin Microbiol Infect https://doi.org/10.1016/j.cmi.2023.12.027.

Variability in plasma rifampicin concentrations and role of SLCO1B1, ABCB1, AADAC2 and CES2 genotypes in Ethiopian patients with tuberculosis. (2024) Sileshi, T., Makonnen, E., Telele, N. F., Barclay, V., Zumla, A., and Aklillu, E. Infect Dis (Lond), 1-12: https://doi.org/10.1080/23744235.2024.2309348.

What is next for BCG revaccination to prevent tuberculosis? (2024) White, R. G., Fiore-Gartland, A. J., Hanekom, W. A., Vekemans, J., Garcia-Basteiro, A. L., Churchyard, G., Rangaka, M. X., Frick, M., Behr, M. A., Hill, P. C., and Mave, V. Lancet Respir Med https://doi.org/10.1016/S2213-2600(24)00009-2.

Other Outputs

Blog: UKAPTB meeting: Strengthening partnerships across the UK to end TB. Jess Potter.

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