Mass Spectrometry
Mass Spectrometry facilities at UCL ensure researchers have timely access to equipment, resources and expertise necessary to undertake world-leading research.
About the STP
Established in 2019, the UCL Mass Spectrometry Science Technology Platform (UCL MS-STP) serves as the central hub for mass spectrometry at UCL, designed to advance research through state-of-the-art technology and expertise. The MS-STP ensures access to basic as well as advanced mass spectrometry analyses and support for all UCL researchers, fostering innovation and collaboration across a diverse range of scientific disciplines. We also work with colleagues from outside UCL and from industry.
Our hub and spoke model
Given that mass spectrometry can be used to study virtually all molecular classes ranging from small molecules, polymers, lipids, carbohydrates, proteins, and protein complexes, the UCL MS-STP is organised in a hub and spoke model whereby each node specialises in particular types of mass spectrometry analyses.
Our currently available expertise are listed below along with key contacts. We are continually trying to add more spokes to the MS-STP in order to further advance the analyses we can offer. If you are interested in something not mentioned below, please contact the MS-STP academic lead Prof. Konstantinos Thalassinos.
About the Hub
The central hub, specialises in bottom-up quantitative proteomics, post-translational modification and crosslinking analyses, as well as native ion mobility and top-down mass spectrometry. These experiments are used to understand the structure and dynamics of proteins and their interactions with other proteins on a cellular scale.
Location
- Darwin Building, Gower Street, London WC1E 6BT
Contacts
About the spoke
The Great Ormond Street Institute of Child Health (GOS ICH) spoke focuses on translational research particularly using targeted proteomics, metabolite and lipid analyses. We offer specialised expertise in the development of assays for the precise measurement and analysis of biomolecules. These capabilities are crucial for advancing biomedical research, particularly in understanding disease mechanisms and the development of biomarkers into tests for the diagnosis and monitoring of therapies.
Locations
30 Guilford St, London WC1N 1EH
Contacts
About the spoke
The School of Pharmacy spoke is dedicated to small molecule and protein identification. This service provides vital insights into the composition and structure of small molecules, which is essential for drug discovery, development, and various chemical analyses. By identifying and characterising small molecules, researchers can advance pharmacological studies and contribute to the development of new medications.
Location
29-39 Brunswick Square, London WC1N 1AX
Contacts
About the spoke
In summary, the facility provides nominal and accurate mass measurements using ESI, EI modes, mass spectrometry based proteomics, metabolomics and sterolomics. LC-MS analyses of small molecules and protein/antibody, LC-MS/MS and MSn, GC-MS analyses using EI and CI ionisation modes, GC-Selective Ion Monitoring (SIM) scans and LC-SIMs and MALDI analysis and peptide finger printing.
Location
Christopher Ingold Building, 20 Gordon Street ,London WC1H 0AJ
Contacts
- Academic Lead:
- Technical Lead/Facility Manager: Kersti Karu
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