Genomics Facilities

Operational for over 15 years, this core facility uses the most up-to-date equipment to support your genomic research requirements. Experienced staff offer support and advice for platform selection, and best practice in a wide range of genomics applications.

Technology. Applications. Education. Collaborate.

The UCL Pathogen Genomics Unit (PGU) is an initiative established by grants from the Medical Research Council (Professor Judith Breuer, Prof Mahdad Noursadeghi) and the UCL/UCLH Biomedical Research Centre. The UCL-PGU undertakes high throughput specialised whole genome sequencing (WGS) of viruses and bacteria from mixed samples by targeted enrichment using capture baits; WGS sequencing of bacterial isolates; specialised RNA-seq for pathogen detection; standard mRNA, ribodepletion and total RNA-Seq.  Non-pathogen material including human exomes can also be sequenced.  The PGU also offers a bioinformatic analysis service.

Technology & Applications. Collaborate

The UCLH Neurogenetics Laboratory is situated within the Department of Molecular Neuroscience at the Institute of Neurology and conducts ground-breaking research on Neurogenetics and Rare Diseases with expertise in long-read sequencing and identification of repeat disease genes. Blood and tissue samples are referred to the laboratory on a daily basis. The laboratory now hosts a DNA bank that holds over 110,000 samples, receives over 11000 samples for testing on an annual basis.

Collaborate. Guidance for users. Panels price lists.   

Potential users should feel free to discuss specialised needs. The Nanostring technology is the perfect tool for validation of NGS and microarray data; for quantification of multiple genes from a limited amount of material; for pathway analysis, expression analyses of defined gene sets, for biomarker validation and more. 

Applications and charges. Collaborate.

We currently provide scientific consultancy services for the generation of mutations using the CRISPR/Cas9 system in zebrafish. We also run a monthly CRISPR/Cas9 Editing validation services using Illumina MiSeq Sequencers. Furthermore, we provide consultancy and training in using the SMARTer ICELL8cx single-cell system for high-throughput single-cell isolation, selection, and processing for single-cell RNA-seq experiments compatible with Illumina NGS applications. Potential users should feel free to discuss specialized needs and available options.

Please contact Ana Faro for queries related to CRISPR/Cas9 editing and Chris Thompson for queries related to the ICELL8cx system. 

Expertise and support at all stages of the research project are offered e.g. help with experimental design, technical services and training to facilitate your research projects requiring genomics and/or genome engineering technologies.

Equipment available. Services provided. Collaborate.