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Short CV
Buzz studied Biochemistry at St Catherine's College, Oxford. He did his PhD (1993-1997) with Paul Nurse at Cancer Research UK, UCL. From 1997-2001, he joined Norbert Perrimon at Harvard Medical School. In 2001, he was awarded a Royal Society URF at UCL and he was appointed as a group leader at UCL’s MRC Laboratory for Molecular Cell Biology in 2007. He was appointed Professor of Cell Biology in 2011. Since 2018, he has also been the director of the Institute for the Physics of Living Systems (IPLS).
Research Interests
Buzz’s lab is interested in the generation of biological form. Since the shape and internal organisation of each cell is determined by a combination of physics, biochemistry and information processing, they use a wide range of techniques to address the problem, including molecular biology, genetics, high-content RNA interference (RNAi) screening, live cell imaging, microfabrication, biophysical techniques and computational modelling.
The wider aims of his labs research are to better understand the evolution of eukaryotic cell shape, to determine how cells regulate their form, and to determine how these processes contribute to normal tissue development and homeostasis and, when they go awry, to the evolution of metastatic cancer.
Key Publications
- Hunter GL, et al (2016). Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Development (Cambridge, England), 143 (13), 2305-2310.
- Dey G, et al (2016). On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype. Trends in Cell Biology, 26 (7), 476-485. doi:10.1016/j.tcb.2016.03.009
- Rodrigues NTL, et al (2015). Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation. Nature, 524 (7566), 489-+. doi:10.1038/nature14496
- Baum D & Baum B (2014). An inside-out origin for the eukaryotic cell. BMC Biol, 12, 76. doi:10.1186/s12915-014-0076-2