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LMCB - MRC Laboratory for Molecular Cell Biology

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Buzz Baum's picture
LMCB Group Leader, UCL Professor of Cell Biology
 
+44 (0)20 7679 3040
LMCB Room 1.02
 
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Cell Morphogenesis

Research Synopsis

The Baum lab is interested in the generation of biological form. Since the shape and internal organisation of each cell is determined by a combination of physics, biochemistry and information processing, we use a wide range of techniques to address the problem, including molecular biology, genetics, high-content RNA interference (RNAi) screening, live cell imaging, microfabrication, biophysical techniques and computational modeling. The wider aims of our research are to better understand the evolution of eukaryotic cell shape, to determine how cells regulate their form, and to determine how these processes contribute to normal tissue development and homeostasis and, when they go awry, to the evolution of metastatic cancer. 

Selected Publications

Hunter GL, et al (2016). Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Development (Cambridge, England), 143 (13), 2305-2310.
Dey G, et al (2016). On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype. Trends in Cell Biology, 26 (7), 476-485. doi:10.1016/j.tcb.2016.03.009
Rodrigues NTL, et al (2015). Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation. Nature, 524 (7566), 489-+. doi:10.1038/nature14496
Baum D & Baum B (2014). An inside-out origin for the eukaryotic cell. BMC Biol, 12, 76. doi:10.1186/s12915-014-0076-2
Lancaster OM, et al (2013). Mitotic rounding alters cell geometry to ensure efficient bipolar spindle formation.  Dev Cell, 25 (3), 270-283. doi:10.1016/j.devcel.2013.03.014
Marinari E, et al (2012). Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. Nature, 484 (7395), 542-545. doi:10.1038/nature10984
Matthews HK, et al (2012). Changes in ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression.  Developmental Cell, 23 (2), 371-383. doi:10.1016/j.devcel.2012.06.003

Funders

Medical Research Council
Wellcome Trust
Cancer Research UK
European Research Council
BBSRC

Research Themes

Cytoskeleton and cell cortex, Polarity and cell shape, Cell-cell interactions, Physics of biological systems, Cell division and cell cycle, Evolution of the cell

Technology

Light microscopy, Translational Research, Bioinformatics, Super-resolution microscopy, Electron Microscopy

People

Jigna Patel (Lab Manager, Research Assistant)
Helen Matthews (Postdoctoral Fellow, CRICK Lab leader)
Gautam Dey (Postdoctoral Fellow)
Francesca Farina (Postdoctoral Fellow)
Nitya Ramkumar (Postdoctoral Fellow)
Katarzyna Plak (Research Associate)
Delyan Mutavchiev (Research Associate)
Roubinet Chantal (Research Associate)
Zaw Win (Research Associate)
Christine Dix (PhD Student)
Sushila Ganguli (CRUK-UCL Centre Clinical PhD Fellow)
Gabriel Tarragon Risa (PhD Student)

Collaborators

Ewa Paluch (LMCB, UK)
Yanlan Mao (LMCB, UK)
Ricardo Henriques (LMCB, UK)
Rob de Bruin (LMCB, UK)
Guillaume Charras (UCL, UK)
Guillaume Salbreux (CRICK, UK)
Finn Werner (UCL, UK)
Jochen Guck (BIOTEC, Germany)
Matthieu Piel (Institut Curie, France)
Manuel Thery (CEA, France)
Laurent Blanchoin (CEA, France)
Catarina Homem (CEDOC, Portugal)
Tim Meyer (UCL, UK)
Wellcome consortium "Archaeal Origins of Eukaryotic Cell Organisation"
CRICK Biological Making Lab: Ravi Desai (CRICK, UK)