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Dr Jess Healy

Dr Jess Healy

UCL Excellence Fellow in Pharmaceutical Chemical Biology

SoP Pharmaceutical & Bio Chemistry

UCL School of Pharmacy

Joined UCL
30th Sep 2013

Research summary

My research interests include multi-drug resistance in bacteria and the development of antimicrobials with novel mechanisms of action to combat this. In particular, I’m interested in using a combination of kinetic target guided synthesis, a process whereby the protein ‘catalyzes’ the synthesis of its own best inhibitor through a combination of concentration effects and optimal size-shape complementarity within the binding site, and more traditional fragment based drug discovery to identify leads for a number of detoxification proteins: glyoxalase I, glyoxalase II and glutathione-S-transferase. Selective and potent probes for these enzymes will allow investigation of their roles in antibiotic resistance and their validation as targets for drug discovery.

Education

University of Aberdeen
PhD, Medical Sciences | 2011
University College Cork
BSc, Chemistry | 2006

Biography

Jess received her BSc. in Chemistry from University College Cork in 2006. PhD studies in Medical Sciences were carried out under the supervision of Prof. Ian R. Booth and Dr Stuart Conway at the University of Aberdeen. This involved the development of small molecule probes targeting a bacterial potassium efflux system, Kef, to investigate the molecular mechanism of activation and to validate it as a target for the development of novel antibacterial agents. Subsequent postdoctoral work, continuing this research, was carried in Dr Stuart Conway’s laboratory at the University of Oxford. Jess was appointed as an Excellence Career Fellow in Pharmaceutical Chemical Biology at the UCL School of Pharmacy in September 2013.

Publications