Dr Shozeb Haider
Dr Shozeb Haider

Selected research

Haider et al. Structure-phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2605-10.

Cancer cells

Islam et al. Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale. Nucleic Acids Res. 2013 Feb 1;41(4):2723-35.

DNA protein

Majkut et al. Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly. Nature Comm (in press)

Dr Shozeb Haider

UCL Excellence Fellow in Computational Medicinal Chemistry

Tel: 0207 753 5883
shozeb.haider@ucl.ac.uk

Responsibilities

  • UCL School of Pharmacy Representative at the RSC
  • Committee member for Molecular Modelling and Graphics Society

Research interests

  • Computational validation and structural bioinformatics of targets in Cancer
  • Structural-phenotype relationship of proteins in Gaucher’s disease
  • Structure-based drug design of Antibacterial compounds
  • Structural Bioinformatics of G-quadruplexes

Teaching interests

Current teaching on the MPharm and MSc:

  • Teacher: Structure-based drug design
  • Teacher: Advanced-structure based drug design (elective module)
  • Project supervisor – MSc projects
  • Project supervisor: 4th year MPharm internal student

Current collaborations and partnerships

  • Activators of proteins – Goutham Narla (Case Western), Mike Ohlmeyer (MSSM), Dual Therapeutics
  • Repositioning of drugs – Prof Mone Zaidi (MSSM)
  • Structure-phenotype relationships in Gaucher’s disease (Prof Pram Mistry, Yale University) and in Congenital Adrenal Hyperplasia (Prof Maria New, MSSM)
  • Structure-based drug design of KPC2 inhibitors – Dr Asad Khan (AMU), UCL

Education

  • BSc/MSc (Biochemistry) 1998, Aligarh Muslim University
  • MRes (Bioinformatics) 1999, University of Leeds
  • PhD in Molecular Biophysics, The Institute of Cancer Research, UK, 2003