Could playing host to parasitic worms help healthy ageing?
4 February 2021
Parasitic worms could hold the key to living longer and free of chronic disease, according to a review of prior evidence written by UCL researchers.
The review, published in eLife, looks at the growing evidence to suggest that losing our ‘old friend’ helminths (parasitic worms), which used to live relatively harmlessly in our bodies, can cause ageing-associated inflammation.
The researchers raise the possibility that carefully controlled, restorative helminth treatments could prevent ageing and protect against diseases such as heart disease and dementia, and warrant further investigation.
Bruce Zhang, BSc student with the UCL Institute of Healthy Ageing and co-author of the review, said: “A decline in exposure to commensal microbes and gut helminths in developed countries has been linked to increased prevalence of allergic and autoimmune inflammatory disorders – the so-called ‘old friends hypothesis’.
“A further possibility is that this loss of ‘old friend’ microbes and helminths increases the sterile, ageing-associated inflammation known as inflammageing.”
Inflammageing is increasingly thought to be a contributory factor to the major diseases of later life, including heart disease, dementia, cancer, chronic obstructive pulmonary disease, osteoporosis, age-related eye disease and – more recently – symptom severity during SARS-CoV-2 (COVID-19) infections.
One theory is that changes in the gut microbiome might cause inflammageing, but until now little consideration has been given to the role of organisms comprising the macrobiome – the ecosystem of macro-organisms – including helminth parasites such as flukes, tapeworms and nematodes.
Helminths have infected humans throughout our evolutionary history, and as a result have become master manipulators of our immune response. Humans, in turn, have evolved levels of tolerance to their presence.
In their article, Zhang and co-author Professor David Gems (UCL Institute of Healthy Ageing, UCL Biosciences), review the evidence for helminth therapy in two areas: treating known inflammatory disorders, such as coeliac disease, and stopping or reversing inflammageing as part of the ageing process.
They reveal how the loss of helminths has so far been linked to a range of inflammatory diseases, including asthma, atopic eczema, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and diabetes. Some studies have shown that natural infection with helminths can alleviate disease symptoms, for example in multiple sclerosis and eczema, while other studies in animal models suggest that intentional infection with helminths could have benefits against disease.
The safer, and perhaps more palatable, option is the concept of using helminth-derived proteins to achieve the same therapeutic benefits. This was tested recently in mice and shown to prevent the age-related decline in gut barrier integrity usually seen with a high-calorie diet. It also had beneficial effects on fat tissue, which is known to be a major source of inflammageing.
The review authors speculate that if helminths have anti-inflammageing properties, you would expect to see lower rates of inflammageing-related disease in areas where helminth infection is more common. There is some evidence to support this. For example, in a region in Eastern India endemic for lymphatic filariasis caused by filarial worms, not a single person with rheumatoid arthritis (RA) tested positive for circulating filarial antigens, whereas a much higher proportion (40%) of people without RA tested positive for the nematode. Other epidemiological studies have shown protection from helminths against type 2 diabetes and blocked arteries.
Professor Gems said: “It goes without saying that improvements in hygiene and elimination of helminth parasites have been of incalculable benefit to humanity, but a cost coupled to this benefit is abnormalities of immune function.
“In the wake of successes during the last century in eliminating the evil of helminths, the time now seems right to further explore their possible benefits, particularly for our ageing population – strange as this may sound.”
- Research paper in eLife
- Professor David Gems’ academic profile
- UCL Institute of Healthy Ageing
- UCL Genetics, Evolution & Environment
- UCL Division of Biosciences
- Filarial nematode (roundworm). Source: NIAID via Flickr (CC BY 2.0)
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Email: chris.lane [at] ucl.ac.uk